医学新知2026，Vol.36Issue(3)：259-267,9.DOI:10.12173/j.issn.1004-5511.202512197
规律食用"药食同源"中药对老年人日常生活活动能力的影响:一项目标仿真试验研究
Effect of regular consumption of"medicine and food homology"traditional Chinese medicine on activities of daily living in the elderly:a target trial emulation
摘要
Abstract
Objective To conduct a target trial emulation(TTE)to explore the effect of regular consumption of"medicine and food homology"(MFH)medicinal plants on activities of daily living(ADL)among the Chinese elderly.Methods Data were derived from the Chinese Longitudinal Healthy Longevity Survey(CLHLS).Participants who entered the cohort in 2008,had normal ADL,and did not regularly consume medicinal ingredients at the age of 60 were selected as the study population.Follow-up data were collected from three surveys conducted between 2011 and 2018.Following the TTE framework,overlap weighting methods were used to emulate the randomization of a randomized controlled trial(RCT).Weighted Cox regression models were employed to investigate the effects of regular MFH consumption on ADL,supplemented by subgroup and multiple sensitivity analyses.Results A total of 10,782 participants were included.During the 10-year follow-up period,1,535(14.2%)participants developed ADL disability.In the population adjusted by cumulative stabilized weights,the regular consumption group showed a 31.7%reduction in the risk of ADL disability compared to the control group[HR=0.683,95%CI(0.483,0.966)].This protective effect was more pronounced in the elderly aged≥80 years[HR=0.654,95%CI(0.451,0.949)],females[HR=0.453,95%CI(0.273,0.754)]and individuals without comorbidities[HR=0.544,95%CI(0.321,0.922)].Sensitivity analyses yielded results consistent with the primary analysis.Conclusion By emulating a target trial,this study demonstrates that regular consumption of MFH medicinal plants significantly reduces the risk of ADL disability in the elderly.Specifically,females and individuals without chronic diseases may derive greater benefits from the consumption of these medicinal plants.关键词
药食同源/中药/日常生活活动能力/目标仿真试验/队列研究Key words
Medicine and food homology/Traditional Chinese medicine/Activities of daily living/Target trial emulation/Cohort study分类
医药卫生引用本文复制引用
王照宇,廖姣姣,李兆基,王卉,陶立元..规律食用"药食同源"中药对老年人日常生活活动能力的影响:一项目标仿真试验研究[J].医学新知,2026,36(3):259-267,9.基金项目
国家自然科学基金面上项目(82474337) （82474337）
北京市自然科学基金-海淀原始创新联合基金(L242058) （L242058）
