中国康复理论与实践2026，Vol.32Issue(3)：329-336,8.DOI:10.3969/j.issn.1006-9771.2026.03.009
基于功能性近红外光谱成像的卒中后焦虑患者前额叶皮质激活特征及机制研究
Activation patterns and mechanism in the prefrontal cortex of post-stroke anxiety patients:a study using func-tional near-infrared spectroscopy
摘要
Abstract
Objective To observe the activation patterns and functional connectivity in the prefrontal cortex of patients with post-stroke anxiety(PSA)using functional near-infrared spectroscopy,in order to explore the underlying neural mech-anism. Methods From December,2024 to September,2025,120 stroke patients were selected in Changzhou De'an Hospital.They were divided into PSA group(n=60)and non-PSA group(n=60)according to the score of Hamilton Anxi-ety Scale(HAMA).All patients wore an 18-channel fNIRS acquisition cap for detection.The differences in rest-ing-state functional connectivity between the frontopolar cortex(FPC)and dorsolateral prefrontal cortex(DLP-FC)were examined in both groups,as well as task-related activation in these brain regions. Results Resting-state functional connectivity analysis revealed no statistically significant difference in network connec-tivity between two groups in the FPC and DLPFC regions(|t|<1.301,P>0.05).Task-related activation results revealed significantly reduced activation in the contralateral FPC of PSA group compared to the non-PSA group(Z=-2.063,P<0.05).Activation levels in this region showed a negative correlation with the scores of HAMA(ρ=-0.201,P=0.028). Conclusion Activation decreased in the contralateral frontal pole during the task state for patients with PSA,and the acti-vation levels negatively correlates with anxiety severities.关键词
脑卒中/卒中后焦虑/功能性近红外光谱/功能连接/皮质激活Key words
stroke/post-stroke anxiety/functional near-infrared spectroscopy/functional connectivity/cortical activation分类
医药卫生引用本文复制引用
杨玲,王庆雷,王洁,徐雯婕,王彤,郭川,钱雪..基于功能性近红外光谱成像的卒中后焦虑患者前额叶皮质激活特征及机制研究[J].中国康复理论与实践,2026,32(3):329-336,8.基金项目
1.国家重点研发计划项目(No.2023YFC3603604) （No.2023YFC3603604）
2.国家自然科学基金青年项目(No.82302882) National Key Research and Development Program of China(No.2023YFC3603604)and National Natural Science Foundation of China(Youth)(No.82302882) （No.82302882）
