中国实验方剂学杂志2026，Vol.32Issue(5)：280-289,10.DOI:10.13422/j.cnki.syfjx.20252004
中医药调控相关信号通路干预胰腺癌研究进展
Regulation of Relevant Signaling Pathways by Traditional Chinese Medicine in Intervention of Pancreatic Cancer:A Review
摘要
Abstract
Pancreatic cancer is a highly malignant solid tumor of the digestive system with extremely poor treatment prognosis.Although its incidence rate is low,its mortality rate is extremely high.In recent years,the number of diagnosed cases worldwide has continued to rise,making pancreatic cancer the sixth leading cause of cancer-related deaths globally.Currently,clinical treatment primarily relies on operation and chemotherapy to suppress tumors.However,these approaches face challenges such as suboptimal efficacy,high postoperative recurrence rates,and severe adverse reactions.Therefore,identifying safe and effective treatment modalities remains a pressing challenge for the medical community.In recent years,research on traditional Chinese medicine(TCM)interventions for pancreatic cancer has increased significantly.Multiple studies have shown that single-herb TCM,TCM formulas,and their derived single compounds can regulate the levels of tumor cell signaling pathways through multiple action targets.They inhibit the development and progression of pancreatic cancer by inhibiting cancer cell proliferation,promoting cell apoptosis,inhibiting tumor angiogenesis,reducing cancer cell invasion and migration capabilities,regulating the cell cycle,and modulating the tumor microenvironment.Additionally,TCM has the advantages of significantly enhancing the anticancer efficacy of chemotherapy drugs and causing fewer adverse reactions.However,the specific action mechanisms by which TCM intervenes in pancreatic cancer remain unclear.Further extensive research is still needed to validate the role of regulating classical signaling pathways such as phosphoinositide 3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR),Wnt/β-catenin,nuclear transcription factor-κB(NF-κB),notch,and hedgehog in the treatment of pancreatic cancer.Therefore,this paper reviewed Chinese and international studies on TCM intervention in pancreatic cancer through relevant signaling pathways in recent years,summarized the potential action mechanisms of TCM in the treatment of pancreatic cancer,and provided references for related research in the future.关键词
胰腺癌/中医药/信号通路/研究进展/综述Key words
pancreatic cancer/traditional Chinese medicine/signaling pathway/research progress/review分类
医药卫生引用本文复制引用
赵全友,赵聪慧,张雨,付依萍,刘玉婷,王笑冉,李占占,苗明三,白莉..中医药调控相关信号通路干预胰腺癌研究进展[J].中国实验方剂学杂志,2026,32(5):280-289,10.基金项目
国家自然科学基金面上项目(82274119) （82274119）
河南省重大科技专项(221100310400) （221100310400）
河南省重点研发专项(251111310400) （251111310400）
河南省中医药科学研究重大专项(2024ZYZD15) （2024ZYZD15）
河南省高等学校重点科研项目(25CY021) （25CY021）
河南省重大公益专项(201300310100) （201300310100）
河南省重点研发专项计划项目(241111311500) （241111311500）
河南省中原学者工作站项目(234400510021),河南省科技攻关项目(252102310532) （234400510021）
