中国输血杂志2026，Vol.39Issue(3)：346-352,7.DOI:10.13303/j.cjbt.issn.1004-549x.2026.03.006
深圳地区献血间隔期与献血不良反应相关性的回顾性队列分析
A retrospective cohort analysis on the association between blood donation intervals and adverse reactions to blood donation in Shenzhen,China
摘要
Abstract
Objective To statistically analyze the association between blood donation intervals and the incidence of ad-verse reactions to blood donation based on blood donor data from Shenzhen.Methods Basic data and records of adverse re-actions to blood donation among voluntary whole blood donors in Shenzhen from January 2017 to June 2025 were extracted.A total of 795 404 whole blood donations were recorded,including 502 743 from males and 292 661 from females,with 1 088 and 751 cases of adverse reactions,respectively.Analyses were performed using R software,including restricted cubic spline(RCS),binary logistic regression,and generalized estimating equations(GEE)to evaluate the correlation between donation intervals and adverse reactions.Results A total of 1 839 cases of adverse reactions were recorded,accounting for 0.23%of the total donations.Both binary logistic regression analysis and the generalized estimating equations(GEE)model showed that there was no significant difference in the incidence of adverse reactions between male and female donors with an interval of≥6 months compared to those with an interval of≥3 months but<6 months.Furthermore,using the 3-5 month interval group as the reference,the analysis indicated that the incidence of adverse reactions significantly increased in males with a 9-12 month interval,while no statistically significant differences were observed across any of the female subgroups.Conclusion There was no significant correlation between adverse reactions to blood donation and the donation interval.Compared with a donation interval of≥6 months,an interval of<6 months does not lead to an increase in the incidence of adverse reactions among male or female donors.The findings of this study may help enhance the willingness of blood donors to participate.关键词
无偿献血/献血间隔期/献血不良反应/相关性分析Key words
voluntary blood donation/donation interval/adverse reactions to blood donation/correlation analysis分类
医药卫生引用本文复制引用
宁理,张艳艳,曾劲峰,黄静雅,黄力勤,邬旭群,伍立桃..深圳地区献血间隔期与献血不良反应相关性的回顾性队列分析[J].中国输血杂志,2026,39(3):346-352,7.基金项目
深圳市医疗卫生三名工程(SZSM202311032) （SZSM202311032）
广东省医学科研基金(B2025582) （B2025582）
深圳市血液中心课题(SZBC202505) （SZBC202505）
