中国实验方剂学杂志2026，Vol.32Issue(5)：322-330,9.DOI:10.13422/j.cnki.syfjx.20251098
基于细胞衰老探讨中医药治疗糖尿病周围神经病变的研究进展
Advances in Diabetic Peripheral Neuropathy Treatment by Traditional Chinese Medicine Based on Cellular Senescence:A Review
摘要
Abstract
Diabetic Peripheral Neuropathy(DPN)is one of the most common and harmful complications of type 2 diabetes.DPN's pathogenesis include high blood sugar-induced oxidative stress,inflammation,and mitochondrial dysfunction.These factors are combined to damage nerve fibers,leading to sensory issues,pain,and numbness.Through a coordinated effect,these factors trigger nerve fiber damage and lead to sensory abnormalities,pain and numbness in limbs,and other symptoms,seriously restricting patients' activities of daily living and mobility.Recent research highlights that cellular senescence plays a critical role in DPN.Cellular senescence is manifested by the loss of cell proliferation ability,and further aggravates nerve damage via oxidative stress,mitochondrial dysfunction,autophagy impairment,inflammatory reaction,and other mechanisms,accelerating DPN occurrence and progression.In terms of medical treatment,current methods focus on blood sugar control,pain relief medicine,and microcirculation improvement,while no therapy has been developed based on cellular senescence.In contrast,traditional Chinese medicine(TCM)shows a unique advantage in DPN prevention and treatment via cellular senescence modulation.TCM emphasizes a holistic approach,as well as syndrome differentiation and treatment,effective in anti-aging and nerve damage repair.Recent studies show that TCM active ingredients,including puerarin,ginsenosides,and berberine,can reduce inflammation,oxidative stress,and apoptosis via signaling pathway regulation,thereby slowing cellular senescence to alleviate nerve damage.Furthermore,TCM compounds such as Buyang Huanwutang,Taohong Siwutang,and Huangqi Guizhi Wuwutang exert synergistic effects on cellular senescence-related pathways to improve nerve health and reduce DPN clinical symptoms.Therefore,this paper reviews the literature related to the interaction between cellular senescence and DPN from the perspective of cellular senescence,summarizing the mechanism of DPN and TCM intervention strategies.关键词
细胞衰老/糖尿病周围神经病变/氧化应激/神经炎症/中医药Key words
cellular senescence/diabetic peripheral neuropathy/oxidative stress/neuroinflammation/traditional Chinese medicine分类
医药卫生引用本文复制引用
马绮娴,韩诗雨,黄慧,田静,韩煦,陈清光,陆灏..基于细胞衰老探讨中医药治疗糖尿病周围神经病变的研究进展[J].中国实验方剂学杂志,2026,32(5):322-330,9.基金项目
上海市科委科研计划项目(22S21900400) （22S21900400）
浦东新区卫生健康委员会2024年度联合攻关项目(PW2024D-12) （PW2024D-12）
上海市中医临床重点实验室项目(20DZ2272200) （20DZ2272200）
上海中医药大学科创项目(YYKC-2021-01-144) （YYKC-2021-01-144）
