中国内镜杂志2026，Vol.32Issue(3)：65-71,7.DOI:10.12235/E20250237
血清可溶性B7-H3和Dickkopf相关蛋白1对早期胃癌患者内镜黏膜下剥离术后复发的预测价值
Clinical predictive value of serum sB7-H3 and DKK1 for recurrence in early gastric cancer patients after endoscopic submucosal dissection
尼力帕尔·阿不都吾甫尔 1麦合木提江·吾斯曼 2管亚茹1
作者信息
- 1. 喀什地区第一人民医院 消化内科,新疆 喀什 844000
- 2. 喀什地区疾病预防控制中心(喀什地区卫生监督所)公共卫生监督科,新疆 喀什 844000
- 折叠
摘要
Abstract
Objective To explore the predictive value of serum soluble B7-H3(sB7-H3)and Dickkopf-related protein 1(DKK1)for recurrence in patients with early gastric cancer(EGC)after endoscopic submucosal dissection(ESD).Methods 133 EGC patients who received ESD treatment from December 2021 to December 2023 were selected as the EGC group,and 133 healthy individuals who underwent physical examinations during the same period were selected as the control group.The expression levels of serum sB7-H3 and DKK1 were compared between the two groups.According to whether there was recurrence after ESD in EGC patients,the patients were further divided into the recurrence group and the non-recurrence group.A multivariate Logistic regression model was used to analyze the independent risk factors influencing recurrence after ESD in EGC patients.The receiver operating characteristic curve(ROC curve)was drawn to analyze the predictive value of serum sB7-H3 and DKK1 for recurrence after ESD.Results The levels of serum sB7-H3 and DKK1 in the EGC group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of serum sB7-H3 and DKK1 in the recurrence group were significantly higher than those in the non-recurrence group,and the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that the depth of invasion was submucosal(O＾R=4.228,95%CI:1.874～9.537),the level of serum sB7-H3 was high(O＾R=4.925,95%CI:1.999～12.133),and the level of DKK1 was high(O＾R=5.262,95%CI:1.933～14.326)were independent risk factors for recurrence of EGC patients after ESD(P<0.05).ROC curve showed that the combined detection of serum sB7-H3 and DKK1 had an AUC of 0.878(95%CI:0.810～0.928)for predicting recurrence after ESD,which was significantly greater than the AUC predicted by serum sB7-H3 and DKK1 alone(Z=2.61,P=0.009;Z=2.75,P=0.006).Conclusion Elevated levels of serum sB7-H3 and DKK1 are independent risk factors affecting the recurrence of EGC patients after ESD.The combined detection of the two has a high clinical application value in predicting the recurrence of EGC patients after ESD.关键词
早期胃癌(EGC)/内镜黏膜下剥离术(ESD)/可溶性B7-H3(sB7-H3)/Dickkopf相关蛋白1(DKK1)/复发Key words
early gastric cancer(EGC)/endoscopic submucosal dissection(ESD)/soluble B7-H3(sB7-H3)/Dickkopf related protein 1(DKK1)/recurrence分类
医药卫生引用本文复制引用
尼力帕尔·阿不都吾甫尔,麦合木提江·吾斯曼,管亚茹..血清可溶性B7-H3和Dickkopf相关蛋白1对早期胃癌患者内镜黏膜下剥离术后复发的预测价值[J].中国内镜杂志,2026,32(3):65-71,7.
