中国比较医学杂志2026，Vol.36Issue(5)：70-91,22.DOI:10.3969/j.issn.1671-7856.2026.01.007
哺乳动物中枢神经疾病中突触修剪的协同与表观调控
Synergistic and epigenetic regulation of synaptic pruning in mammalian central nervous system disorders
摘要
Abstract
Synaptic pruning,as a core process in neural development and functional maintenance in the mammalian central nervous,relies on precise molecular and cellular regulation and is crucial for constructing efficient and stable neural networks.Dysregulation of synaptic-pruning mechanisms disrupts the dynamic equilibrium of neural connections,closely associated with the onset and progression of various central nervous system diseases.The mechanisms underlying glial cell-mediated synaptic elimination are not yet fully understood;however,multiple signals promoting or inhibiting synaptic clearance are known to be involved in collectively regulating this complex process.In-depth analysis of the cellular and molecular mechanisms governing synaptic formation and elimination can not only reveal the underlying pathogenesis of central nervous system diseases,but may also provide a theoretical basis for their early diagnosis and intervention,and for the development of innovative therapies.Further exploration of synaptic-pruning mechanisms has the potential to result in critical breakthroughs in tackling neurological disorders.关键词
突触修剪/中枢神经系统疾病/胶质细胞/表观遗传Key words
synaptic pruning/central nervous system diseases/glial cells/epigenetics分类
医药卫生引用本文复制引用
仵美佳,黄辉..哺乳动物中枢神经疾病中突触修剪的协同与表观调控[J].中国比较医学杂志,2026,36(5):70-91,22.基金项目
河南省自然科学基金(252300423198). （252300423198）
