中国比较医学杂志2026，Vol.36Issue(5)：92-102,11.DOI:10.3969/j.issn.1671-7856.2026.05.008
心血管类器官模型的研究进展
Research progress of cardiovascular organoid models
摘要
Abstract
Cardiovascular disease is currently the disease with the highest incidence and mortality rate globally,but pathogenesis research and drug development for this condition still face significant challenges,partly because of the limitations of traditional research models.Two-dimensional(2D)cell cultures make it difficult to simulate the microenvironment in vivo,while animal models have species differences that cannot fully reproduce the physiological and pathological characteristics of the human cardiovascular system.With the continuous breakthrough of stem cell technology,organoid model research has developed rapidly,providing innovative tools for cardiovascular mechanism research and drug development.Cardiovascular organoids are microtissue models constructed with stem cells under three-dimensional(3D)culture conditions in vitro;they can highly simulate the structure,composition,and function of the human heart and blood vessels,significantly improving the physiological relevance of research.This paper systematically reviews their construction strategies and application progress,discussing current limitations and future directions.关键词
心血管疾病/类器官/干细胞/疾病建模Key words
cardiovascular disease/organoids/stem cell/disease modeling分类
医药卫生引用本文复制引用
向晨,蔡宏文..心血管类器官模型的研究进展[J].中国比较医学杂志,2026,36(5):92-102,11.基金项目
国家自然科学基金面上项目(81973579) （81973579）
浙江省公益技术应用研究(实验动物)项目(2017C37182) （实验动物）
浙江省中医药科研基金项目(2023ZL411,2023ZL422). （2023ZL411,2023ZL422）
