中国比较医学杂志2026，Vol.36Issue(5)：103-113,11.DOI:10.3969/j.issn.1671-7856.2026.05.009
cGAS-STING信号通路参与阿尔茨海默病的研究进展
Research progress on the cGAS-STING signaling pathway in patients with Alzheimer's disease
摘要
Abstract
Alzheimer's disease(AD)is a neurodegenerative disorder primarily characterized by cognitive impairment and executive function deficits.As a crucial innate immune pathway,abnormal activation of the cyclic GMP-AMP synthase-stimulator of interferon gene(cGAS-STING)signaling pathway in AD has attracted considerable attention.This review discusses the involvement of the cGAS-STING signaling pathway in AD via mechanisms including β-amyloid deposition and abnormal tau protein aggregation,oxidative stress and mitochondrial dysfunction,neuroinflammation and glial cell abnormalities,synaptic dysfunction,vascular dysfunction,gut microbiota dysbiosis,and autophagy dysfunction,as well as considering relevant research on potential therapeutic interventions in the cGAS-STING signaling pathway for the treatment of AD.This review aims to reveal the role of abnormal activation of the cGAS-STING signaling pathway as a cause of AD pathogenesis and as a potential interventional target for the treatment of AD.关键词
cGAS-STING/阿尔茨海默病/病理机制/治疗/进展Key words
cGAS-STING/Alzheimer's disease/pathogenesis/treatment/progress分类
医药卫生引用本文复制引用
吴亚博,许玉珉,刘诗雨,刘源,杨鑫,闫化雨..cGAS-STING信号通路参与阿尔茨海默病的研究进展[J].中国比较医学杂志,2026,36(5):103-113,11.基金项目
国家科技重大专项(2024ZD0522202) （2024ZD0522202）
河南省博士后基金项目(HN2022083) （HN2022083）
河南省医学科技攻关计划省部共建项目(SBGJ202302101) （SBGJ202302101）
河南省科技发展计划项目(242102311255) （242102311255）
河南省卫生健康委国家中医药传承创新中心科研专项(2023ZXZX1004). （2023ZXZX1004）
