中国比较医学杂志2026，Vol.36Issue(5)：125-136,12.DOI:10.3969/j.issn.1671-7856.2026.05.010
基于AMPK信号通路探讨中医药治疗糖尿病肾脏疾病的研究进展
Research progress on traditional Chinese medicine for treating diabetic kidney disease based on AMPK signaling pathway
摘要
Abstract
The global incidence of diabetes mellitus has recently shown a steep rise.Diabetic kidney disease(DKD),as one of the most prevalent microvascular complications,has accordingly become the primary cause of end-stage renal disease.There is an urgent need to identify safe,reliable,cost-effective,and low-side-effect medications for early interventions for DKD to delay disease progression.Pathological studies have revealed that the adenylate monophosphate-activated protein kinase(AMPK)signaling pathway plays a central role in DKD pathogenesis,offering a novel therapeutic direction by regulating inflammatory responses,oxidative stress,autophagy,apoptosis,lipid metabolism,ferroptosis,and other biological processes.Traditional Chinese medicine(TCM)has been shown to effectively alleviate edema,proteinuria,and declining renal function,while significantly improving patients'quality of life—a critical consideration for early DKD intervention.Notably,terpenoids,flavonoids,phenolic compounds,alkaloids,and several TCM formulations(e.g.,Shuilu Dihuang capsules,Angelica Sinensis Blood Tonic soup,Tangshenning formula,Jinlida granules,and Colquhounia Root tablets)have exhibited significant AMPK pathway-targeting effects.This review comprehensively synthesizes recent domestic and international advancements in TCM-mediated regulation of the AMPK signaling pathway in DKD,aiming to provide a reference for understanding the mechanisms and clinical efficacy of TCM in treating DKD.关键词
糖尿病肾脏疾病/腺苷酸活化蛋白激酶/信号通路/中医药Key words
diabetic kidney disease/adenosine monophosphate-activated protein kinase/signaling pathway/traditional Chinese medicine分类
医药卫生引用本文复制引用
孙雨杉,侯亚威,潘广辉,肖振卫..基于AMPK信号通路探讨中医药治疗糖尿病肾脏疾病的研究进展[J].中国比较医学杂志,2026,36(5):125-136,12.基金项目
山东省老年医学学会科技发展计划项目(LKJGG2021W113) （LKJGG2021W113）
山东中医药大学专业学位研究生教学案例库建设项目(XJAL2021002). （XJAL2021002）
