中国卫生事业管理2026，Vol.43Issue(3)：300-306,7.
基于LDA模型的2010～2024年多重耐药菌研究热点与主题演化分析
Research Hotspots and Theme Evolution Analysis of Multi Drug-Resistant Bacteria from 2010 to 2024 Based on The LDA Model
摘要
Abstract
Objective To systematically explore the research hotspots,evolutionary trajectories and driving factors of multi drug-resistant organisms(MDROs)in China from 2010 to 2024,thereby offering an empirical basis for optimizing prevention strategies and guiding future scientific priorities.Methods Based on Wanfang and China National Knowledge Infrastructure(CNKI)databases,3,726 relevant Chinese-language academic abstracts were retrieved and screened.Latent Dirichlet Alloca-tion(LDA)were employed for text mining to identify core research themes.The evolutionary trends in thematic prominence were investigated through a multi-dimensional temporal analysis,incorporating metrics such as annual publication share and compound annual growth rate(CAGR).Results Seven prominent thematic clusters were identified,which were categorized into three over-arching domains,including foundational mechanistic exploration(52.81%),clinically driven practice(32.91%),and public health integration(13.93%).Further investigation revealed an evolutionary trajectory in China's MDROs research,characterized by a progression from descriptive epidemiological surveys towards in-depth mechanistic elucidation and data-driven modeling,and ultimately advancing to systematic,precision-based research for prevention and control decision-making.Conclusion Re-search on MDROs in China exhibits strong policy responsiveness and practice-oriented characteristics,with its focus dynamically shifting in alignment with national policies,technological advances,and clinical demands.Greater emphasis should be placed on fostering interdisciplinary integration,promoting the development of AI-powered precision prevention and control systems ground-ed in real-world evidence,and enhancing the generation and global dissemination of localized intervention strategies.These ef-forts are essential to effectively address the challenges of the"post-antibiotic era".关键词
多重耐药菌/LDA模型/研究热点/主题演化/医院感染防控Key words
Multi Drug-Resistant Organisms/LDA Model/research hotspots/topic evolution/hospital infection preven-tion and control分类
医药卫生引用本文复制引用
汪慧,刘亚清,饶菲菲,姜峰,龚丽雯,杜思娴..基于LDA模型的2010～2024年多重耐药菌研究热点与主题演化分析[J].中国卫生事业管理,2026,43(3):300-306,7.基金项目
教育部人文社会科学研究规划基金"个性化健康需求下的慢病防控服务协同机制及其改善策略研究"(21YJA630062) （21YJA630062）
湖北省软科学研究项目"湖北省科技与产业创新障碍分析及对策研究"(2025EDA070) （2025EDA070）
