中国比较医学杂志2026，Vol.36Issue(6)：90-101,12.DOI:10.3969/j.issn.1671-7856.2026.06.009
乳酸化修饰在骨关节退变性疾病中的研究进展
Research progress on lactylation modification in osteoarticular degenerative diseases
摘要
Abstract
Post-translational modifications(PTMs)are crucial for regulating protein functions.As a novel PTM,lactylation has emerged as a recent research hotspot,participating in pathological processes such as tumor progression and inflammation;it dynamically regulates gene expression and protein activity,which is significant for metabolic-immune coordination.In degenerative osteoarthropathy(such as osteoarthritis and rheumatoid arthritis),cartilage metabolic imbalance is closely associated with dynamic changes in lactylation,involving pathological links such as cartilage matrix degradation,synovial inflammation,and abnormal bone remodeling.Current clinical interventions cannot block disease progression.This review systematically summarizes the molecular mechanisms of lactylation(including lactate metabolism as well as histone and non-histone lactylation),regulatory factors(enzymes,environment,and molecular tools),and its role in degenerative osteoarthropathy,covering expression changes in cartilage tissues,correlation with arthritis progression,and biomarker studies in clinical models.Lactylation affects joint degeneration by regulating glycolysis-oxidative phosphorylation balance,inflammatory factor expression,and extracellular matrix metabolism.Targeted regulation strategies(such as CRISPR editing and small-molecule inhibitors)hold promise as novel therapeutic approaches.Future research needs to overcome technical limitations in detection,decipher the dynamic lactylation network through interdisciplinary collaboration,and promote its clinical translation in early diagnosis,precise intervention,and personalized treatment.关键词
乳酸化修饰/骨关节退变性疾病/骨关节炎/软骨组织/代谢失衡/靶向治疗Key words
lactylation modification/degenerative osteoarthropathy/osteoarthritis/cartilage tissue/metabolic imbalance/targeted therapy分类
医药卫生引用本文复制引用
侯承钰,张亮..乳酸化修饰在骨关节退变性疾病中的研究进展[J].中国比较医学杂志,2026,36(6):90-101,12.基金项目
国家自然科学基金面上项目(82172462,81972136) （82172462,81972136）
江苏省第六期"333工程"优秀青年人才科研项目(11). （11）
