中国畜牧兽医2026，Vol.53Issue(4)：1830-1839,10.DOI:10.16431/j.cnki.1671-7236.2026.04.018
丁酸梭菌的生理功能及其在反刍动物生产中的应用
Physiological Functions of Clostridium butyricum and Its Application in Ruminant Production
摘要
Abstract
Clostridium butyricum is a Gram-positive,anaerobic,spore-forming bacterium widely distributed in environments such as soil and animal intestines.It possesses various physiological functions,including butyrate production,regulation of gut microbiota,enhancement of immunity,and maintenance of the intestinal barrier.As a natural microecological agent,Clostridium butyricum holds promising application prospects in ruminant production.Its accurate identification relies on a systematic approach combining 16S rRNA gene sequencing with physiological and biochemical characterization.The core probiotic mechanism of this bacterium lies in its production of butyrate,which directly supplies energy to intestinal epithelial cells,strengthens the expression of tight junction proteins to reinforce the physical barrier,and promotes protein secretion and regulatory T cell(Treg)differentiation through epigenetic pathways such as histone deacetylase(HDAC)inhibition,thereby synergistically maintaining intestinal homeostasis and immune balance.These probiotic effects can significantly optimize rumen fermentation in ruminants,increase the production of total volatile fatty acids and fiber digestibility,and promote the proliferation of fiber-degrading bacteria.This review systematically summarizes the probiotic mechanisms of Clostridium butyricum and its applications in ruminant production,with a focus on analyzing its role in optimizing rumen fermentation,improving production performance,and maintaining intestinal health.The aim is to provide theoretical support for constructing a health-focused and efficient production regulation system centered on Clostridium butyricum,thereby contributing to the enhancement of quality,efficiency,and green development in the ruminant livestock industry.关键词
丁酸梭菌/生理功能/反刍动物/瘤胃发酵/生产性能Key words
Clostridium butyricum/physiological functions/ruminants/rumen fermentation/production performance分类
农业科技引用本文复制引用
关银香,郭国庆,刘洋,薛树媛,杜立银..丁酸梭菌的生理功能及其在反刍动物生产中的应用[J].中国畜牧兽医,2026,53(4):1830-1839,10.基金项目
宁夏回族自治区重点研发计划项目(2024BBF01010) （2024BBF01010）
