中国畜牧兽医2026，Vol.53Issue(4)：1840-1851,12.DOI:10.16431/j.cnki.1671-7236.2026.04.019
沙门菌与宿主细胞的互作机制:从胃酸耐受到肠上皮细胞定植
Interaction Mechanism of Salmonella with Host Cells:From Gastric Acid Tolerance to Intestinal Epithelial Cell Colonization
摘要
Abstract
Salmonella is an important zoonotic enteric pathogen whose pathogenic mechanism relies on overcoming multiple defence barriers of host cells.In recent years,significant progress has been made in the study of the interaction mechanisms between Salmonella and host cells,especially in the key steps,important molecules,and regulatory networks involved in Salmonella's invasion of host cells.The authors systematically elucidate the process by which Salmonella overcomes physicochemical barriers,invades host cells,and ultimately remodels the intracellular microenvironment.It focuses on how Salmonella delivers multiple effector proteins through its typeⅢ secretion system,synergistically targeting host cells and thereby mediating key aspects such as host cytoskeleton remodelling,membrane transport manipulation,and lipid metabolism reprogramming.Understanding the interaction mechanisms of Salmonella's invasion of host cells provides crucial theoretical support for overcoming the limitations of traditional antibacterial strategies and developing novel anti-infection regimens that target host-pathogen interactions.关键词
沙门菌/宿主-病原体互作/上皮屏障/毒力因子/细菌入侵/细胞内定植Key words
Salmonella/host-pathogen interaction/epithelial barrier/virulence factors/bacterial invasion/intracellular colonization分类
农业科技引用本文复制引用
杨海峰,陈鋆,殷韶杰,陈晓兰,王婧,解肖羽婷,卢霞,朱建民..沙门菌与宿主细胞的互作机制:从胃酸耐受到肠上皮细胞定植[J].中国畜牧兽医,2026,53(4):1840-1851,12.基金项目
江苏省高等学校基础科学(自然科学)研究重大项目(24KJA230001) （自然科学）
江苏省科技副总项目(FZ20250796) （FZ20250796）
泰州市社会发展项目(TSL202522) （TSL202522）
江苏农牧科技职业学院科研揭榜挂帅项目(NSF2024JB01) （NSF2024JB01）
