中国比较医学杂志2026，Vol.36Issue(6)：122-133,12.DOI:10.3969/j.issn.1671-7856.2026.06.012
一氧化氮对血脑屏障的影响研究进展
Research advances in the impact of nitric oxide on the blood-brain barrier
摘要
Abstract
The blood-brain barrier(BBB)plays a critical role in maintaining brain homeostasis.BBB dysfunction is closely associated with various neurodegenerative diseases and acute brain injuries,which impair brain defense mechanisms and can exacerbate the progression of pathological conditions.Nitric oxide(NO),an important biological signaling molecule,exerts a wide range of effects on the central nervous system,influencing both physiological and pathological states.This review summarizes the production and metabolism of NO and their effects on BBB permeability,followed by an introduction to the role of NO in pathological conditions such as cerebral ischemia-reperfusion injury,neurodegenerative diseases,and brain tumors.NO regulates BBB integrity through the regulation of tight junction proteins and vascular endothelial growth factor receptor 2(VEGFR2).The review also delves into the potential of NO as a therapeutic target in drug delivery and gene therapy,and explores its potential to enhance drug penetration across the BBB.These explorations provide novel perspectives for future therapeutic strategies.关键词
血脑屏障/一氧化氮合酶/血管内皮细胞/紧密连接蛋白Key words
blood-brain barrier/nitric oxide synthase/endothelial cells/tight junction proteins分类
医药卫生引用本文复制引用
辛靖怡,杨美雯,洪芬芳,杨树龙..一氧化氮对血脑屏障的影响研究进展[J].中国比较医学杂志,2026,36(6):122-133,12.基金项目
国家自然科学基金(82360880) （82360880）
江西省自然科学基金(20232ACB206057,20212BAB206092) （20232ACB206057,20212BAB206092）
江西省教育厅科技研究重点项目(GJJ218104) （GJJ218104）
江西省高等学校教学改革研究课题(JXJG-22-130-1) （JXJG-22-130-1）
南昌大学抚州医学院校级重点项目(fykj202301). （fykj202301）
