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焦虑早期改善对抑郁症患者急性期治疗结局影响的多中心随访研究

卞雯 魏镜 王刚 陈巧灵 朱刚 王学义 张楠 司天梅 于欣 吕晓珍 周书喆 邓雨桐 刘琦 王婧 孙静雯 田红军 张克让

中国心理卫生杂志2026，Vol.40Issue(4)：277-283,7.
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中国心理卫生杂志2026，Vol.40Issue(4)：277-283,7.DOI:10.3969/j.issn.1000-6729.2026.04.01

焦虑早期改善对抑郁症患者急性期治疗结局影响的多中心随访研究

A multicenter follow-up study of impact of early improvement in anxiety symptoms on acute treatment outcomes in major depressive disorder patients with anxiety

卞雯 1魏镜 2王刚 3陈巧灵 4朱刚 5王学义 6张楠 7司天梅 1于欣 1吕晓珍 1周书喆 1邓雨桐 1刘琦 1王婧 1孙静雯 1田红军 8张克让9

作者信息

  • 1. 北京大学第六医院,北京大学精神卫生研究所,国家卫生健康委员会精神卫生学重点实验室 (北京大学),精神心理疾病国家临床医学研究中心 (北京大学第六医院),北京 100083
  • 2. 北京协和医院心理医学科,北京 100730
  • 3. 北京安定医院,北京 100088
  • 4. 大连市第七人民医院精神科,辽宁 大连 116023
  • 5. 中国医科大学附属第一医院精神科,沈阳 110001
  • 6. 河北医科大学附属第一医院精神科,石家庄 050023
  • 7. 天津医科大学总医院神经内科,天津 300041
  • 8. 天津市第四中心医院,天津 300140
  • 9. 山西医科大学第一医院精神卫生科,太原 030001
  • 折叠

摘要

Abstract

Objective:To investigate the impact of early anxiety improvement on acute treatment outcomes in major depression disorder(MDD)patients with anxiety.Methods:This study involved a post hoc analysis of data from a multi-center,multi-stage prospective study.Totally 210 participants with MDD and anxiety were enrolled from nine hospitalsin China.Patients'demographic and clinical characteristics were collected at baseline.Depression and anxiety symptoms were assessed with the Hamilton Depression Rating Scale-17(HAMD-17)and Hamilton Anxiety Rating Scale(HAMA)at baseline,week 2 and week 8.Early anxiety improvement was defined as a≥20%or more reduction in HAMA scores at week 2.Multivariable logistic regression was used to explore associa-tions between early anxiety improvement and depression(HAMD-17)and anxiety(HAMA)response/remission at week 8.Results:Early anxiety improvement was observed in 134 patients(63.8%).Early anxiety improvement in-creased the likelihood of achieving depression response(OR=5.44,95%CI:1.90-15.67)and remission(OR=2.61,95%CI:1.16-5.89)after 8-week acute treatment period,early anxiety improvement also increased the like-lihood of achieving anxiety response(OR=3.70,95%CI:1.40-9.76)and remission(OR=3.28,95%CI:1.43-7.53)at 8-week.Conclusion:Early improvement in anxiety symptoms is a significant predictor of favorable a-cute-phase treatment outcomes in depressed patients with comorbid anxiety.

关键词

抑郁症/焦虑症状/早期改善/有效/临床治愈

Key words

major depression disorder/anxiety/early improvement/response/remission

分类

医药卫生

引用本文复制引用

卞雯,魏镜,王刚,陈巧灵,朱刚,王学义,张楠,司天梅,于欣,吕晓珍,周书喆,邓雨桐,刘琦,王婧,孙静雯,田红军,张克让..焦虑早期改善对抑郁症患者急性期治疗结局影响的多中心随访研究[J].中国心理卫生杂志,2026,40(4):277-283,7.

基金项目

国家科技部科创新2030——重大项目"抑郁症的前瞻性临床队列研究"(2021ZD0200600),国家重点基础研究发展计划"MDD客观诊断指标的建立与药物个体化干预"(2013CB531305) （2021ZD0200600）

中国心理卫生杂志

OACHSSCD

1000-6729

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