中国防痨杂志2026，Vol.48Issue(4)：468-476,9.DOI:10.19982/j.issn.1000-6621.20250444
广东省英德市无结核社区试点地区三类重点人群结核分枝杆菌感染率调查及相关因素分析
Survey of Mycobacterium tuberculosis infection rate and analysis of associated factors among three priority populations in Yingde's zero-TB community pilot areas,Guangdong Province
摘要
Abstract
Objective:To investigate the prevalence of Mycobacterium tuberculosis(MTB)infection and its associated factors among key populations screened with the recombinant Mycobacterium tuberculosis fusion protein(EC)assay in Yingde's zero-TB community pilot areas.This study aimed to provide data support and a scientific basis for optimizing the national zero-TB community screening strategy.Methods:The study included close contacts of active pulmonary tuberculosis patients,diabetic patients,and self-presenting respiratory disease patients who underwent EC-based screening in two pilot townships(Wangbu,Shihuipu)of Yingde City in 2023.The study analyzed the EC screening coverage,MTB infection prevalence,and employed multivariable binary logistic regression to identify factors associated with MTB infection in each subgroup.Results:A total of 1524 key individuals were screened,with a screening rate of 87.44％(1524/1743).Among them,142 tested positive,resultingin an infection rate of 9.32％(142/1524).The screening rate among close contacts was 88.43％(757/856)with an infection rate of 10.30％(78/757);for diabetic patients,the rates were 82.97％(570/687)and 8.42％(48/570),respectively;and for self-presenting respiratory disease patients,the rates were 98.73％(233/236)and 9.87％(23/233).Multivariable logistic regression analysis indicated that among household contacts of tuberculosis patients,close contact with bacteriologically confirmed patients(OR=1.972,95％CI:1.178-3.301)and self-reported smoking history(OR=2.047,95％CI:1.012-4.140)were associated with MTB infection.Among respiratory disease patients seeking medical care,male sex was associated with MTB infection(OR=2.740,95％CI:1.088-6.903).Conclusion:The EC test demonstrated feasibility for investigating tuberculosis infection rates.Populations requiring focused attention include close contacts of etiologically positive index cases,close contacts with a smoking history,and male self-presenting patients with respiratory symptoms.关键词
结核/重组融合蛋白质类/分枝杆菌感染/筛查/因素分析,统计学Key words
Tuberculosis/Recombinant fusion proteins/Mycobacterium infections/Screening/Factor analysis,statistical分类
医药卫生引用本文复制引用
王勇兵,钟粤相,付秀英,张盈,温文沛,周芳静,杨应周,罗济伦..广东省英德市无结核社区试点地区三类重点人群结核分枝杆菌感染率调查及相关因素分析[J].中国防痨杂志,2026,48(4):468-476,9.基金项目
广东省终结结核流行综合干预示范区试点项目 Pilot Project of Comprehensive Intervention Demonstration Zone for Ending Tuberculosis Epidemic in Guangdong Province （）
