内科2026，Vol.21Issue(1)：17-22,6.DOI:10.16121/j.cnki.cn45-1347/r.2026.01.03
裸花紫珠颗粒治疗肝硬化门静脉高压性胃病的临床效果
Clinical effect of Callicarpa nudiflora granules in the treatment of cirrhotic portal hypertensive gastropathy
摘要
Abstract
Objective To investigate the clinical effect of Callicarpa nudiflora granules in the treatment of cirrhotic portal hypertensive gastropathy.Methods A total of 60 patients diagnosed with cirrhotic PHG were enrolled as research subjects and randomly divided into a control group or an observation group,with 30 patients in each group.The control group received conventional symptomatic treatment including oral propranolol hydrochloride tablets and esomeprazole magnesium enteric-coated tablets,based on which the observation group was additionally treated with Callicarpa nudiflora granules,and both groups were treated continuously for 2 courses(6 months in total).The endoscopic efficacy,histopathological changes of the gastric mucosa,liver function indicators(alanine aminotransferase[ALT],aspartate aminotransferase[AST]),and comprehensive clinical efficacy were compared between the two groups.Results After 6 months of treatment,the total endoscopic effective rate of the observation group was 93.33%(28/30),which was higher than the 63.33%(19/30)of the control group,with a statistically significant difference(P＜0.05);in the observation group,endoscopic mucosal hyperemia,edema,and mosaic-like lesions were significantly alleviated,and pathological changes such as gastric mucosal erosion and bleeding were improved compared with those before treatment and those in the control group.After 6 months of treatment,the serum levels of ALT and AST in the observation group were lower than those in the control group(all P＜0.05).After 6 months of treatment,the total clinical effective rate of the observation group was 93.33%(28/30),which was higher than the 70.00%(21/30)of the control group,with a statistically significant difference(P＜0.05).Conclusion Callicarpa nudiflora granules can effectively improve gastric mucosal lesions in patients with cirrhotic PHG,promote mucosal repair,and synergistically improve liver function,with significant clinical efficacy.关键词
裸花紫珠/肝硬化/门静脉高压性胃病/临床疗效Key words
Callicarpa nudiflora/Cirrhosis/Portal hypertensive gastropathy/Clinical efficacy分类
医药卫生引用本文复制引用
沈海容,雷植鹏,王大东,吴志芳..裸花紫珠颗粒治疗肝硬化门静脉高压性胃病的临床效果[J].内科,2026,21(1):17-22,6.基金项目
广西壮族自治区中医药管理局科研课题项目(GXZYZ20210140) （GXZYZ20210140）
