中国药物经济学2026，Vol.21Issue(2)：34-37,41,5.DOI:10.12010/j.issn.1673-5846.2026.02.006
不同麻醉药物对老年手术患者术后短期记忆和长期认知功能的影响
Effects of Different Anesthetic Drugs on the Short-term Memory and Long-term Cognitive Function of Elderly Surgical Patients after Surgery
摘要
Abstract
Objective To explore the effects of different anesthetic drugs on the short-term memory and long-term cognitive function of elderly surgical patients after surgery.Methods A total of 100 elderly surgical patients admitted to Zhangjiagang Third People's Hospital from January to April 2024 were selected.They were randomly divided into propofol intravenous anesthesia and sevoflurane inhalation anesthesia,with 50 cases in each group.The short-term memory,long-term cognitive function,serum inflammatory mediators,and neurotransmitter levels of the two groups were compared.Results Over time after the surgery,the forward digit span score and the backward digit span score in both groups gradually increased.Moreover,the backward digit span score in propofol intravenous anesthesia was higher than that in sevoflurane inhalation anesthesia at 3 days and 7 days after the surgery(P＜0.05).The scores of the Mini-Mental State Examination(MMSE)scale in both groups decreased compared to those before the surgery at one week after the surgery(P＜0.05).One month after the surgery,the MMSE scores of both groups began to rise.propofol intravenous anesthesia's MMSE score recovered to the preoperative level at 3 months after the surgery,while sevoflurane inhalation anesthesia's score recovered to the preoperative level at 6 months after the surgery.Moreover,the MMSE scores of propofol intravenous anesthesia at 1 month and 3 months after the surgery were higher than those of sevoflurane inhalation anesthesia(P＜0.05).At the time of surgery end(T1),the serum C-reactive protein(CRP)levels of both groups were higher than those at the induction of anesthesia(T0).The increase in B group was greater than that in A group,and the difference between the groups was statistically significant(P＜0.05).At 24 hours after the surgery(T2),the serum CRP level of propofol intravenous anesthesia began to decrease,while that of sevoflurane inhalation anesthesia continued to increase.The difference between the groups was statistically significant(P＜0.05).At 48 hours after the surgery(T3),the serum CRP level of propofol intravenous anesthesia returned to the preoperative level,while that of sevoflurane inhalation anesthesia was still higher than the preoperative level.The difference between the groups was statistically significant(P＜0.05).At T1,the serum acetylcholine(ACh)levels of both groups were lower than those at T0.The decrease in B group was greater,and the difference between the groups was statistically significant(P＜0.05).At T2,the serum ACh level of propofol intravenous anesthesia began to rise,while that of sevoflurane inhalation anesthesia continued to decrease.The difference between the groups was statistically significant(P＜0.05).At T3,the serum ACh level of propofol intravenous anesthesia returned to the preoperative level,while that of sevoflurane inhalation anesthesia was still lower than the preoperative level.The difference between the groups was statistically significant(P＜0.05).Conclusion Compared with sevoflurane inhalation anesthesia,propofol intravenous anesthesia has more advantages when used in elderly surgical patients.It is beneficial for the recovery of short-term retrograde memory and long-term cognitive function,and has a smaller impact on serum inflammatory mediators and neurotransmitter levels.关键词
老年手术患者/七氟醚吸入麻醉/环泊酚静脉麻醉/短期记忆/长期认知功能Key words
Elderly patients undergoing surgery/Sevoflurane inhalation anesthesia/Cyclopofol intravenous anesthesia/Short-term memory/Long-term cognitive function分类
医药卫生引用本文复制引用
许永浩,邓飞,王力仲,陆艳萍..不同麻醉药物对老年手术患者术后短期记忆和长期认知功能的影响[J].中国药物经济学,2026,21(2):34-37,41,5.基金项目
张家港市科技计划指导性立项项目(ZKYL2303) （ZKYL2303）
