浙江大学学报（医学版）2026，Vol.55Issue(1)：72-76,5.DOI:10.3724/zdxbyxb-2025-0521
闭环脊髓神经接口联合康复训练治疗不完全性脊髓损伤患者一例
Closed-loop spinal neural interface combined with rehabilitation training for incomplete spinal cord injury:a case report
摘要
Abstract
Spinal cord injury(SCI)is a major cause of motor disability.Epidural electrical stimulation(EES)has emerged as a promising neuromodulation technique and has been extensively investigated in recent years for promoting functional recovery after SCI.This case report describes a patient who sustained a thoracic SCI four months ago due to a fall from height.Following surgical intervention and conventional rehabilitation,the patient's lower limb muscle strength remained at grade C on the American Spinal Injury Association(ASIA)impairment scale.After implantation of a closed-loop spinal neural interface for EES,the patient underwent a regimen of continuous stimulation with spatially targeted configurations and multimodal rehabilitation training.This intervention led to progressive recovery,including the achievement of voluntary single-joint movements,independent standing,and assisted walking.At the 16-week follow-up,the patient's ASIA grade improved from C to D.Improvements were also noted in sensory and autonomic functions in addition to motor recovery.The overall rehabilitation outcomes were substan-tially better than those typically reported for chronic-phase SCI patients in the literature.Importantly,no implant-related infections or neurological complications were observed.These results indicate that the combination of closed-loop spinal neural interface-enabled EES and structured rehabilitation holds significant potential as a therapeutic strategy.关键词
脊髓损伤/硬膜外电刺激/闭环脊髓神经接口/神经重塑/运动功能/病例报告Key words
Spinal cord injury/Epidural electrical stimulation/Closed-loop spinal neural interface/Neural remodeling/Motor function/Case report分类
医药卫生引用本文复制引用
冯琛,朱君明,张建民,许科帝..闭环脊髓神经接口联合康复训练治疗不完全性脊髓损伤患者一例[J].浙江大学学报（医学版）,2026,55(1):72-76,5.基金项目
浙江省自然科学基金(LR23H180002) （LR23H180002）
浙江省"尖兵领雁+X"科技计划(2026C01009)This study was supported by Zhejiang Provincial Natural Science Foundation of China (LR23H180002) and "Pioneer" and "Leading Goose" R&D Program of Zhejiang (2026C01009). （2026C01009）
