中国实用妇科与产科杂志2026，Vol.42Issue(2)：243-247,5.DOI:10.19538/j.fk2026020121
妇科门诊女性阴道念珠菌定植多中心流行病学调查
Multicenter epidemiological investigation of vaginal candida colonization in women visiting gynecology outpatient department
摘要
Abstract
Objective To investigate the colonization rate of vaginal Candida,its influencing factors,colonizing species,and their in vitro drug susceptibility among women of reproductive age attending gynecology outpatient clinics in China,thereby providing new epidemiological data for the prevention and treatment of vulvovaginal candidiasis.Methods A multicenter cross-sectional survey was conducted from January 2020 to December 2022.A total of 1072 eligible women of reproductive age attending gynecology outpatient clinics were enrolled from eight tertiary hospitals in Beijing,Shanghai,Nanjing,Guangzhou,Kunming,Nanning,Zhengzhou,and Jinan.Vaginal secretions were collected for routine leukorrhea examination,Candida culture,species identification,and in vitro antimicrobial susceptibility testing.Related influencing factors were also investigated and analyzed.Results Among the 1072 participants who completed the study,the vaginal Candida colonization rate was 9.4％(101/1072).The distribution of species was as follows:Candida albicans 59.4％,Candida glabrata 18.8％,Candida tropicalis 11.9％,and Candida parapsilosis 6.9％.Univariate analysis showed that bathing in tubs,vaginal douching with cleaning and antibacterial agents,humid living environment,increased vaginal discharge,and abnormal odor of vaginal discharge were significantly associated with Candida colonization(P＜0.05).Conclusions Candida can colonize the vagina of women of reproductive age,with Candida albicans being the predominant species.Bathing in tubs,vaginal douching with cleaning and antibacterial agents,humid living environment,increased vaginal discharge,and abnormal odor of vaginal discharge are influencing factors for vaginal Candida colonization.There are differences in drug susceptibility among colonizing strains.关键词
阴道念珠菌/定植率/流行病学/影响因素Key words
vaginal candida/colonization rate/epidemiology/influencing factors分类
医药卫生引用本文复制引用
范瑞强,张建伟,潘伟华,刘朝晖,潘红炬,廖志刚,廖万清,袁娟娜,梁雪芳,徐莲薇,任青玲,姜丽娟,陈萍,钟洁,刘雁峰..妇科门诊女性阴道念珠菌定植多中心流行病学调查[J].中国实用妇科与产科杂志,2026,42(2):243-247,5.基金项目
广东省华润顺峰药业外用药院士工作站建设项目(广东省科技厅2017B090904025) Construction of the Academician Workstation for External Medications of Guangdong China Resources Shunfeng Pharmaceutical(Guangdong Provincial Department of Science and Technology 2017B090904025) （广东省科技厅2017B090904025）
