中国药物经济学2026，Vol.21Issue(2)：117-121,5.DOI:10.12010/j.issn.1673-5846.2026.02.022
左归丸调控免疫-炎症网络治疗肾阴虚证的研究现状
Current Research Status of Zuogui Pills Regulating the Immune Inflammatory Network for the Treatment of Kidney Yin Deficiency Syndrome
摘要
Abstract
Kidney yin deficiency syndrome is closely associated with immune inflammation.Insufficient vital qi can lead to immunosuppression,while yin deficiency and internal heat can activate inflammatory signaling pathways.Zuogui Pills,a classic traditional Chinese medicine formula for nourishing yin and replenishing the kidney,exhibits potential for multi-target regulation of the immune-inflammatory network.This article systematically reviews the material basis of Zuogui Pills and its mechanisms in regulating the immune-inflammatory network.It is found that Zuogui Pills can restore immune homeostasis by modulating the balance of T cell subsets,macrophage polarization,inhibiting the release of pro-inflammatory factors,promoting the expression of anti-inflammatory factors,and regulating key signaling pathways such as NF-κB,MAPK.Zuogui Pills demonstrates significant immunomodulatory and anti-inflammatory effects in neurological,reproductive,and orthopedic diseases.This article aims to explore the mechanisms by which Zuogui Pills regulates the body's immune-inflammatory network in treating kidney yin deficiency syndrome,providing a new perspective for revealing the scientific connotations of this formula.关键词
左归丸/肾阴虚证/免疫-炎症网络/研究现状Key words
Zuogui Pills/Kidney yin deficiency syndrome/Immune-inflammatory network/Current research status分类
医药卫生引用本文复制引用
赵旭,陈龙娇,李平..左归丸调控免疫-炎症网络治疗肾阴虚证的研究现状[J].中国药物经济学,2026,21(2):117-121,5.基金项目
深圳市基础研究面上项目(JCYJ20210324134610029) （JCYJ20210324134610029）
