中国医科大学学报2026，Vol.55Issue(3)：227-233,7.DOI:10.12007/j.issn.0258-4646.2026.03.006
CT影像组学对肾上腺非结节样增生患者高血压发生风险的预测价值
Predictive value of computed tomography radiomics for thie risk of hypertension in patients with non-nodular adrenal hyperplasia
摘要
Abstract
Objective To explore the relationship between non-nodular adrenal hyperplasia and the risk of hypertension using a com-puted tomography(CT)radiomics assessment.Methods The data of 452 patients with non-nodular adrenal hyperplasia were retrospec-tively analyzed.The Least Absolute Shrinkage and Selection Operator model was used to select the radiomics features,univariate regres-sion analysis was used to screen the CT morphological features,and multivariable regression analysis was used to construct corresponding models.By integrating CT morphological and radiomics features,comprehensive models were constructed,and a subgroup analysis was performed.The receiver operating characteristic(ROC)curve,Delong test,calibration curve,and decision curve were used to analyze and evaluate the performance of the models.Results Based on a ratio of 8∶2,360 patients were assigned to the training set and 92 were assigned to the validation set.Eleven of the 2 446 radiomics features were selected to construct the radiomics model.Six risk factors associated with hypertension were identified using univariate regression analysis:area,volume,and junction thickness of both adrenal glands.The areas under the ROC curve of the comprehensive,radiomics,and CT morphological models were 0.839,0.831,and 0.620,respectively,in the training set,and 0.804,0.802,and 0.693,respectively,in the validation set.The calibration curve,decision curve,and Delong test showed that the performance of the radiomics model was superior to that of the CT morphological feature model(P<0.05),and that there was no significant difference between the radiomics and comprehensive models(P>0.05).Subgroup analysis showed that the model performed consistently in the age and the sex subgroups(P>0.05).Conclusion The radiomics model was the most effective in predicting hypertension.When a patient is diagnosed with non-nodular adrenal hyperplasia by CT,the increase in adrenal morphology and texture heterogeneity may indicate an increase in the risk of hypertension.关键词
肾上腺非结节样增生/高血压/影像组学/计算机断层扫描Key words
non-nodular adrenal hyperplasia/hypertension/radiomics/computed tomography分类
医药卫生引用本文复制引用
范晨,陈维鹏,张晓玲,朱依谆..CT影像组学对肾上腺非结节样增生患者高血压发生风险的预测价值[J].中国医科大学学报,2026,55(3):227-233,7.基金项目
澳门科学技术发展基金(FDCT0001/2024/AKP) （FDCT0001/2024/AKP）
