中国医科大学学报2026，Vol.55Issue(3)：234-239,6.DOI:10.12007/j.issn.0258-4646.2026.03.007
外周血Hsa-circRNA0001380水平对急性前壁ST段抬高型心肌梗死后心力衰竭的预测价值
Diagnostic value of peripheral blood Hsa-circRNA0001380 level in heart failure after acute anterior wall ST-segment elevation myocardial infarction
摘要
Abstract
Objective To explore the predictive value of Hsa-circRNA0001380 for heart failure after emergency percutaneous coro-nary intervention(PCI)in patients with acute anterior wall ST-segment elevation myocardial infarction(STEMI).Methods Sixty-two patients with acute anterior wall STEMI who underwent emergency PCI at the Dalian University of Technology Affiliated Cen-tral Hospital between January and December 2022 were enrolled.Twenty-two healthy volunteers served as controls.In the STEMI group,Hsa-circRNA0001380 levels were compared across the different cardiac function indicators.Receiver operating characteri-stic(ROC)curves were used to eva-luate the predictive value of heart failure after acute anterior wall STEMI.Results Hsa-cir-cRNA0001380 expression was significantly increased in patients with STEMI than in controls(P<0.01)and correlated with Killip classification and left ventricular ejection fraction(LVEF)(both P<0.01).Patients were divided into the high-level group(≥0.012 7,n=31)and low-level group(<0.012 7,n=31)according to the median value of Hsa-circRNA0001380.Hsa-cir-cRNA0001380 was positively correlated with left ventricular end-diastolic volume(r=0.594)and NT-proBNP(r=0.644)but negatively correlated with LVEF(r=-0.838)(all P<0.01).The area under the ROC curve for predicting heart failure was 0.953.Conclusion Peripheral blood Hsa-circRNA0001380 is significantly upregulated in acute anterior wall STEMI,especially in patients with heart failure,and may be a novel molecular marker for predicting the progression of heart failure after acute anterior wall STEMI.关键词
Hsa-circRNA0001380/急性前壁ST段抬高型心肌梗死/心力衰竭Key words
Hsa-circRNA0001380/acute anterior-wall ST-segment elevation myocardial infarction/heart failure分类
医药卫生引用本文复制引用
贾圣英,赵福禄,陈转霞,石晨,王力,孙志军,王传合,关琳,田雪,张胜波,徐红梅,蒋丽..外周血Hsa-circRNA0001380水平对急性前壁ST段抬高型心肌梗死后心力衰竭的预测价值[J].中国医科大学学报,2026,55(3):234-239,6.基金项目
辽宁省自然科学基金(2025-MS-367) （2025-MS-367）
大连市医学重点专科"登峰计划"高峰项目(2023ZZ058) （2023ZZ058）
