中国中医药信息杂志2026，Vol.33Issue(4)：13-17,5.DOI:10.19879/j.cnki.1005-5304.202507619
基于多组学的特发性肺纤维化中医药研究思路与方法
TCM Research Thinking and Methods of Idiopathic Pulmonary Fibrosis Based on Multi-omics
摘要
Abstract
Idiopathic pulmonary fibrosis(IPF)has become an important public health problem to be solved due to its increasing incidence,limited treatment options and poor prognosis.Clinical application of TCM in the treatment of IPF can effectively relieve the symptoms of patients,reduce the frequency of acute exacerbation,and improve the quality of life of patients.Multi-omics is an extension of systems biology,integrating multi-dimensional data such as the genome,transcriptome,proteome and metabolome to reveal the biological basis of disease progression at the molecular level.This article combined multi-omics with TCM theories,and based on an integrated research framework encompassing"disease-syndrome-compound-effect",and excavated the key biomarkers of TCM in the diagnosis and treatment of IPF,so as to provide theoretical reference for the standardization and objectification of TCM syndrome differentiation and treatment.关键词
特发性肺纤维化/多组学/辨证论治Key words
idiopathic pulmonary fibrosis/multi-omics/syndrome differentiation and treatment分类
医药卫生引用本文复制引用
高晨曦,祝宏江,吕晓东,王天娇,赵仲雪,刘勇明,刘妍彤,杨丽..基于多组学的特发性肺纤维化中医药研究思路与方法[J].中国中医药信息杂志,2026,33(4):13-17,5.基金项目
国家自然科学基金区域创新发展联合基金(U24A20777) （U24A20777）
全国中医临床优秀人才研修项目(2025年) （2025年）
辽宁省教育厅高校基本科研项目储备项目(2024-JYTCB-059) （2024-JYTCB-059）
辽宁省中医优秀人才培养项目(2024年) （2024年）
辽宁省科技厅联合计划(2024-MSLH-316) （2024-MSLH-316）
