中国肿瘤生物治疗杂志2026，Vol.33Issue(2)：111-119,9.DOI:10.3872/j.issn.1007-385x.2026.02.001
肿瘤靶向性复制溶瘤病毒治疗肿瘤的潜能和挑战
Potential and challenges of tumor-targeted replicating oncolytic virus in tumor treatment
摘要
Abstract
The clinical benefits of tumor immunotherapy are still limited by non-responses or resistance of cancer patients.Tumor-targeted replicating oncolytic viruses(TOV)can act as"initiators"and"catalysts"for immunotherapy,converting"cold"tumors into"hot"tumors,with controllable safety and good tolerance.This article systematically reviews the mechanism,clinical progress,and key challenges of TOV and possible solutions to overcome the challenges,focusing on discussing the impact of the host immune system on TOV,the development of more effective TOV platforms,strategies for efficient intravenous administration of TOV,the choice of preclinical animal evaluation models with better clinical predictive value,the optimization of treatment scheduling of combination therapy and directions for future development.This review discusses the potential of TOV as a pivotal synergistic and catalytic platform in cancer immunotherapy,proposing novel strategies to enhance immune responses and achieve long-term efficacy against solid tumors.关键词
溶瘤病毒/肿瘤微环境/免疫治疗/催化剂/治疗时序Key words
oncolytic virus/tumor microenvironment/immunotherapy/catalyst/treatment scheduling分类
医药卫生引用本文复制引用
王丽虹,王尧河..肿瘤靶向性复制溶瘤病毒治疗肿瘤的潜能和挑战[J].中国肿瘤生物治疗杂志,2026,33(2):111-119,9.基金项目
国家自然科学基金(82403870) （82403870）
空军特色医学中心快速响应课题(2024ZXKXKT039) （2024ZXKXKT039）
