中国医科大学学报2026，Vol.55Issue(3)：272-277,6.DOI:10.12007/j.issn.0258-4646.2026.03.013
NLRP3炎症小体介导细胞焦亡在阿尔茨海默病中的作用机制
Mechanism of NLRP3 inflammasome induced-pyroptosis in Alzheimer disease
摘要
Abstract
Alzheimer disease(AD)is a common neurodegenerative disorder characterized by cognitive decline and progressive memory loss.Pyroptosis releases inflammatory factors such as interleukin-1β and interleukin-18,which then exacerbate inflammation and neuronal death,and intensify pathological changes such as amyloid β-protein deposition and excessive phosphorylation of Tau protein in AD.The NLRP3 inflammasome is an important inducer of pyroptosis.Studies have shown that amyloidβ-protein deposition,excessive phosphoryla-tion of Tau protein,mitochondrial dysfunction,oxidative stress,endoplasmic reticulum stress,and lysosomal damage can all activate the NLRP3 inflammasome.This article reviews the pathological connection between NLRP3 inflammasome-induced pyroptosis and AD,and summarizes the amelioration of the pathological progression of AD to provide new therapeutic approaches for AD in the future.关键词
阿尔茨海默病/细胞焦亡/NLRP3炎症小体/神经炎症/治疗策略Key words
Alzheimer disease/pyroptosis/NLRP3 inflammasome/neuroinflammation/therapeutic strategy分类
医药卫生引用本文复制引用
杨宇,叶秋燕,杨丰鸽,李建辉,李雪缘,李林青,李虹霖..NLRP3炎症小体介导细胞焦亡在阿尔茨海默病中的作用机制[J].中国医科大学学报,2026,55(3):272-277,6.基金项目
国家自然科学基金(82105035) （82105035）
黑龙江省自然科学基金(LH2023H064) （LH2023H064）
