中国现代医生2026，Vol.64Issue(6)：48-53,6.DOI:10.3969/j.issn.1673-9701.2026.06.009
固元通脉汤对肾虚血瘀型阳痿患者及舌苔菌群微生态的影响
Effects of Guyuan Tongmai decoction on erectile dysfunction of kidney deficiency and blood stasis pattern and the microecology of tongue coating microbiota
摘要
Abstract
Objective Preliminary study on the efficacy of Guyuan Tongmai decoction in patients with erectile dysfunction of kidney deficiency and blood stasis pattern and its impact on tongue coating microflora ecology.Methods Twenty healthy males admitted to the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine from September 2022 to September 2024 were selected as control group(only providing tongue coating microbiota in a healthy state);Concurrently,20 patients with erectile dysfunction of the kidney deficiency and blood stasis pattern were selected as patient group and treated with Guyuan Tongmai decoction.Tongue coating microbiota samples were collected from both groups.Microbial information from these samples was obtained using 16S ribosomal RNA gene sequencing(16S rRNA sequencing).Penile hemodynamic parameters,including peak systolic velocity(PSV),end-diastolic velocity(EDV),and resistance index(RI)were measured and recorded via color doppler ultrasound before and after treatment.Observations were made on the following parameters before and after treatment:The international index of erectile function-5(IIEF-5)score,traditional Chinese medicine syndrome score(TCMS),penile hemodynamic indicators,and the differences in tongue coating microbiota composition across the groups.Results Compared with pretreatment,post-treatment results demonstrated:IIEF-5 scores showed significant improvement(P<0.01);TCMS were significantly reduced(P<0.01);Penile hemodynamic parameters exhibited the following changes:PSV and RI significantly increased(P<0.01);EDV significantly decreased(P<0.05).Genus-level analysis showed no significant differences(P>0.05)in the top 20 genera by relative abundance among control group,pre-and post-treatment of patient group.Heatmap visualization,post-treatment samples exhibited significantly increased microbial abundance compared to pre-treatment state.Significantly enriched genera of linear discriminant analysis effect size results showed that control group:Campylobacter;Pre-treatment of patient group:Veillonella;Post-treatment of patient group:Oenococcus.Conclusion Guyuan Tongmai decoction significantly improves the IIEF-5 scores,TCMS,and penile hemodynamic parameters in patients with erectile dysfunction of the kidney deficiency and blood stasis pattern.Guyuan Tongmai decoction significantly modulates the relative abundance of the top 20 most abundant bacterial genera in tongue coating microbiota.关键词
固元通脉汤/肾虚血瘀型阳痿/舌苔菌群/16S rRNA测序/阴茎血流动力学Key words
Guyuan Tongmai decoction/Erectile dysfunction of kidney deficiency and blood stasis pattern/Tongue coating microbiota/16S rRNA sequencing/Penile hemodynamics分类
医药卫生引用本文复制引用
王家秀,刘欢,卢明峰,潘孝志,王婉悦,周晶,朱璋龙,丁维..固元通脉汤对肾虚血瘀型阳痿患者及舌苔菌群微生态的影响[J].中国现代医生,2026,64(6):48-53,6.基金项目
国家自然科学基金资助项目(82060809) （82060809）
贵州省中医药管理局中医药、民族医药科学技术研究专项课题(QZYY-2024-069) （QZYY-2024-069）
