中国现代医生2026，Vol.64Issue(6)：54-61,8.DOI:10.3969/j.issn.1673-9701.2026.06.010
丹黄散改善糖尿病肾病的机制研究
Investigating the mechanism of Danhuang powder in ameliorating diabetic nephropathy
摘要
Abstract
Objective To investigate the mechanisms of Danhuang powder(DHS)treats diabetic nephropathy(DN)using network pharmacology and molecular docking.Methods Active compounds were retrieved from TCMSP and HERB;DN-related targets were obtained from GeneCards,TTD,and OMIM.Overlapping targets were identified(Venny),followed by protein-protein interaction(PPI)construction and topological analysis to determine core targets.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses characterized relevant biological processes and pathways.A herb-compound-disease-target network was built.Key compound-target interactions were validated by molecular docking(AutoDock Vina)and visualized in PyMOL.Results 165 common targets were identified.Core targets included AKT serine/threonine kinase 1,tumor protein p53,signal transducer and activator of transcription 3 and nuclear factor kappa B subunit 1.GO enrichment yielded 2805 biological processes,225 molecular functions and 81 cellular components;KEGG analysis identified 169 significant pathways.Molecular docking showed strong binding affinities between principal DHS compounds and core targets.Conclusion DHS exerts therapeutic effects on DN via multi-component,multi-target and multi-pathway mechanisms,supporting its clinical application and further pharmacological investigation.关键词
丹黄散/糖尿病肾病/网络药理学/分子对接Key words
Danhuang powder/Diabetic nephropathy/Network pharmacology/Molecular docking分类
医药卫生引用本文复制引用
胡柔,王安宇,黄菁,张黔丽,赵胜..丹黄散改善糖尿病肾病的机制研究[J].中国现代医生,2026,64(6):54-61,8.基金项目
贵州省卫生健康委科学技术基金项目(gzwkj2025-184) （gzwkj2025-184）
贵州省科技计划项目(黔科合基础-ZK[2022]一般553) （黔科合基础-ZK[2022]一般553）
