中国现代中药2026，Vol.28Issue(3)：549-557,9.DOI:10.13313/j.issn.1673-4890.20241211002
川芎中21种元素分析及风险评估
Analysis and Risk Assessment of 21 Elements in Ligusticum chuanxiong
摘要
Abstract
Objective:To determine the content of 21 elements in Ligusticum chuanxiong herbs,stems,leaves,rhizosphere soil,and irrigation water,and assess the risk of toxic elements in the medicinal material,including Pb,Cd,As,Hg,Cu,Al,Cr,and Ni,aiming to provide a basis for the quality and safety evaluation of L.chuanxiong.Methods:After microwave digestion,inductively coupled plasma mass spectrometry(ICP-MS)was employed to analyze 21 elements.Based on the results,health risks were assessed.Results:The 21 elements exhibited good linearity and precision,with limits of detection ranging from 0.001 to 0.612 μg·kg-1,and recovery rates of 85%-115%.The mass fractions of K,Ca,Fe,Al,and Na in L.chuanxiong were greater than 50 mg·kg-1,accounting for a high proportion.The hazard index(HI)of harmful elements in five batches of samples was less than 1,indicating a low and acceptable non-carcinogenic risk.The carcinogenic risk(CR)of Pb and As was lower than 1×10-4,indicating a low and acceptable carcinogenic risk.There was a significant positive correlation between the heavy metal content in L.chuanxiong herbs and that in the stems and leaves.Conclusion:The multi-element analysis method established in this study demonstrates satisfactory specificity and sensitivity.Combined with risk assessment technology,it can provide technical support for the quality safety evaluation of L.chuanxiong.关键词
川芎/重金属/元素/电感耦合等离子体质谱法/风险评估Key words
Ligusticum chuanxiong Hort./heavy metal/element/ICP-MS/risk assessment分类
医药卫生引用本文复制引用
王丹丹,郭愿生,金红宇,王莹,林永强,左甜甜,魏锋..川芎中21种元素分析及风险评估[J].中国现代中药,2026,28(3):549-557,9.基金项目
国家重点研发计划项目(2022YFC3501505) （2022YFC3501505）
2023年度国家药品标准制修订研究课题(2023Z07) （2023Z07）
国家自然科学基金青年科学基金项目(82504738) （82504738）
