浙江大学学报（医学版）2026，Vol.55Issue(2)：154-162,9.DOI:10.3724/zdxbyxb-2025-0785
空间组学应用于肺纤维化机制解析和治疗研究进展
Spatial omics in pulmonary fibrosis:advancing mechanistic insights and therapeutic strategies
摘要
Abstract
Pulmonary fibrosis,a group of chronic interstitial lung diseases charac-terized by persistent inflammation and aberrant deposition of fibrous connective tissue,poses a significant therapeutic challenge,with idiopathic pulmonary fibrosis(IPF)being its most representative and severe form.Spatially resolved omics technologies—encompassing spatial metabolomics,transcriptomics,and proteomics—have emerged as transformative tools that preserve the architectural context of tissues while enabling high-throughput,visualization-capable analysis of metabolites,genes,and proteins.Spatial metabolomics facilitates the visualization and intelligent annotation of metabolic landscapes;spatial transcriptomics deciphers regional heterogeneity and refines the molecular timeline of early disease events;and spatial proteomics elucidates protein interaction networks and uncovers novel drug-resistance mechanisms.Collectively,spatial omics provides unprece-dented insights into disease pathogenesis,offering a powerful framework for advancing precision diagnosis,identifying therapeutic targets,and guiding drug development.This article synthesizes recent progress in applying spatial omics to pulmonary fibrosis research,underscoring its potential to translate into more effective clinical strategies.关键词
肺纤维化/空间代谢组学/空间转录组学/空间蛋白质组学/质谱成像/综述Key words
Pulmonary fibrosis/Spatial metabolomics/Spatial transcriptomics/Spatial proteomics/Mass spectrometry imaging/Review分类
医药卫生引用本文复制引用
彭云鹏,谢云云,杨帆,乔欣,田燕歌..空间组学应用于肺纤维化机制解析和治疗研究进展[J].浙江大学学报（医学版）,2026,55(2):154-162,9.基金项目
国家科技重大专项(2024ZD0522905) （2024ZD0522905）
河南省科技发展计划(232301420020)This study was supported by National Science and Technology Major Project of China (2024ZD0522905) and Henan Provincial Science and Technology Development Plan (232301420020). （232301420020）
