中国现代中药2026，Vol.28Issue(3)：592-604,13.DOI:10.13313/j.issn.1673-4890.20250807001
基于UPLC-Q-TOF-MS/MS的杏荷止咳糖浆化学成分鉴别及指纹图谱分析
Analysis of Chemical Components and Fingerprint of Xinghe Zhike Syrup Based on UPLC-Q-TOF-MS/MS
摘要
Abstract
Objective:To qualitatively analyze the chemical components and establish the fingerprint of Xinghe Zhike Syrup.Methods:Ultra-high performance liquid chromatography-quadrupole-time-of-flight tandem mass spectrometry(UPLC-Q-TOF-MS/MS)was employed to identify the chemical components of Xinghe Zhike Syrup.Ultra-high performance liquid chromatography-evaporative light scattering detector(UPLC-ELSD)was employed to establish the fingerprints of 15 batches of Xinghe Zhike Syrup,and the Similarity Evaluation System for Chromatographic Fingerprint of Traditional Chinese Medicine was used for similarity evaluation.Results:A total of 41 compounds in Xinghe Zhike Syrup were identified,mainly including flavonoids,phenolic acids,terpenoids,and saponins.There were 17 common peaks in the fingerprints of the 15 batches of Xinghe Zhike Syrup,with similarities ranging from 0.949 to 0.999,and 16 common peaks were identified.Conclusion:The chemical components of Xinghe Zhike Syrup were clarified,and the established fingerprinting method for Xinghe Zhike Syrup is simple and accurate,providing a reference for improving its quality evaluation standard.关键词
杏荷止咳糖浆/指纹图谱/超高效液相色谱-四级杆-飞行时间串联质谱法/超高效液相色谱-蒸发光散射检测器法Key words
Xinghe Zhike Syrup/fingerprint/UPLC-Q-TOF-MS/MS/UPLC-ELSD分类
医药卫生引用本文复制引用
徐有坤,祁飞亚,陈小燕,刘祎,杨蓉..基于UPLC-Q-TOF-MS/MS的杏荷止咳糖浆化学成分鉴别及指纹图谱分析[J].中国现代中药,2026,28(3):592-604,13.基金项目
贵州省科技计划项目(黔科合支撑[2022]一般185) （黔科合支撑[2022]一般185）
