中国中医药信息杂志2026，Vol.33Issue(4)：50-56,7.DOI:10.19879/j.cnki.1005-5304.202509221
基于改进Bron-Kerbosch算法探究《临证指南医案》补气类药物用药规律
Exploration on the Medication Law of Qi-tonifying Drugs Applied in Lin Zheng Zhi Nan Yi An Based on the Improved Bron-Kerbosch Algorithm
摘要
Abstract
Objective To investigate the core strategies and identification points of clinical application of qi-tonifying drug scenarios of Ye Tianshi.Methods Taking the prescriptions of Lin Zheng Zhi Nan Yi An as the data source,a prescription dataset was constructed.The universal set lift(ULift)was used to calculate the highly correlated drugs of the target drugs in the prescription dataset and the correlation analysis was performed.The improved Bron-Kerbosch(BK)algorithm was used to calculate the community distribution of the high correlation drug set of the target drugs and drug analysis was performed.Results A total of 2 401 prescriptions with 624 kinds of Chinese materia medica were included,and 115 kinds of Chinese materia medica were used≥30 times.The main qi-tonifying drugs used≥30 times in the prescriptions of the Lin Zheng Zhi Nan Yi An were Ginseng Radix et Rhizoma,Glycyrrhizae Radix et Rhizoma Praeparata cum Melle,Atractylodis Macrocephalae Rhizoma,Glycyrrhizae Radix et Rhizoma,Jujubae Fructus,Dioscoreae Rhizoma,Astragali Radix,etc.The drug relevance analysis demonstrated two groups of compatibility and contraindication patterns of various drugs.The drug network analysis revealed 27 drug communities among seven qi-tonifying drugs.The compatibility patterns associated with different qi-tonifying drugs were not entirely identical.Conclusion Ye Tianshi's clinical application of qi-tonifying drugs varies according to different pathological mechanisms.Ginseng Radix et Rhizoma and Atractylodis Macrocephalae Rhizoma are often combined with warm yang promoting qi drugs and used to dry dampness and treat water.Jujubae Fructus,Glycyrrhizae Radix et Rhizoma Praeparata cum Melle,and Astragali Radix are used in combination to treat deficiency syndrome.Qi tonifying drugs are often combined with calming herbs to treat restlessness.Huangqi Guizhi Wuwu Decoction is modified to treat qi deficiency complicated by limb bi-syndrome.关键词
临证指南医案/全集提升度/改进Bron-Kerbosch算法/补气药/用药规律Key words
Lin Zheng Zhi Nan Yi An/universal set lift index/improved Bron-Kerbosch algorithm/qi-tonifying drugs/medication law分类
医药卫生引用本文复制引用
郭姝男,张迪,李海燕..基于改进Bron-Kerbosch算法探究《临证指南医案》补气类药物用药规律[J].中国中医药信息杂志,2026,33(4):50-56,7.基金项目
安徽省科技重大专项(202303a07020001) （202303a07020001）
中国中医科学院科技创新工程创新团队(CI2021B002) （CI2021B002）
中国中医科学院中医药信息研究所培育中医药语言与认知人工智能重点实验室项目(ZZSYS-1901-CZ) （ZZSYS-1901-CZ）
