中国现代中药2026，Vol.28Issue(3)：614-624,11.DOI:10.13313/j.issn.1673-4890.20250925008
绿原酸治疗中枢神经系统疾病作用及其机制研究进展
Research Progress in Effects and Mechanisms of Chlorogenic Acid in Treating Central Nervous System Diseases
摘要
Abstract
Currently,long-term use of clinical therapeutic drugs for central nervous system(CNS)diseases is prone to diminished efficacy and adverse reactions.As a natural polyphenolic compound,chlorogenic acid(CGA)has been proven to possess significant central neuroprotective activity.It exhibits multi-targeted and multi-pathway synergistic therapeutic mechanisms,which mainly include inhibiting inflammatory signaling axes and the release of pro-inflammatory factors to exert anti-inflammatory effects,enhancing antioxidant enzyme activity to alleviate oxidative stress damage,regulating synaptic expression and hippocampal synaptic plasticity,stabilizing mitochondrial function to inhibit neuronal apoptosis and ferroptosis,and regulating the microbiota-neuroimmune crosstalk network via the gut-brain axis.This review summarizes the molecular mechanisms through which CGA exerts therapeutic effects on Alzheimer's disease(AD),Parkinson's disease(PD),epilepsy,stroke,depression,anxiety,spinal cord injury(SCI),chronic pain,and post-traumatic stress disorder(PTSD),as well as the innovative applications of related nano-delivery technologies and combined therapeutic strategies.This review aims to comprehensively clarify the multidimensional neuroprotective mechanisms of CGA,thereby providing new ideas and a theoretical basis for the development of related drugs and the prevention and treatment of CNS diseases.关键词
绿原酸/中枢神经系统/抗氧化/神经炎症/神经退行性/临床转化Key words
chlorogenic acid/central nervous system/antioxidation/neuroinflammation/neurodegeneration/clinical translation分类
医药卫生引用本文复制引用
陈沫,李珍,王蕾,王翻红,董惠娟,闫洛美,郝娟..绿原酸治疗中枢神经系统疾病作用及其机制研究进展[J].中国现代中药,2026,28(3):614-624,11.基金项目
新疆维吾尔自治区自然科学基金面上项目(2202D01A326) （2202D01A326）
新疆维吾尔自治区自然科学基金青年科学基金项目(2023D01C211) （2023D01C211）
