遵义医科大学学报2026，Vol.49Issue(3)：280-287,8.
运动干预对中老年2型糖尿病患者体脂成分和肝脏脂肪的影响:随机对照试验研究
The effects of exercise intervention on body lipid composition and liver fat in middle-aged and elderly patients with type 2 diabetes mellitus:a randomized controlled trial
摘要
Abstract
Objective To systematically compare the effects of a personalized exercise intervention program on body fat composition and liver fat metabolism among middle-aged and elderly patients with type 2 diabetes melli-tus(T2DM).Methods This study adopted a prospective,randomized,controlled,open-label trial design.A to-tal of 80 patients diagnosed with T2DM were enrolled.The intervention group(n=40)received the personalized exercise prescription(moderate to high-intensity aerobic and resistance training)in twelve weeks,while the con-trol group(n=40)received routine health education.Participants were included after questionnaire screening and a one-week adaptive training period(compliance rate ≥70％).This study used the twelfth-week's body fat percentage as the primary outcome measure,and the secondary outcome measures included bod mass index(BMI),liver fat-controlled attenuation parameter(CAP),liver stiffness value(E value),liver function,and glycolipid metabolism indicators,etc.Independent-sample T-tests or Mann-Whitney U tests were used for inter-vention group comparisons,and analysis of covariance(ANCOVA)was applied to adjust for the influence of baseline data on outcome measures.Results A total of 80 participants were included,with 40 in the intervention group[age:(58.75±9.01)years]and 40 in the control group[age:(61.10±9.95)years];43.8％partici-pants were female.Per-protocol analysis showed that BMI demonstrated a significant decreasing trend subsequent to the exercise intervention(ΔBMI=-0.20 kg/m2,P＜0.05),with a notable between-group variance(P＜0.001).Within the intervention group,high-density lipoprotein cholesterol(HDL-C)showed a significant in-creasing trend(ΔHDL-C=0.07 mmol/L,P＜0.05).After adjusting for baseline values using ANCOVA,Gly-cated hemoglobin(HbA1c)in the intervention group decreased significantly(Adjusted P=0.015).However,no significant differences were observed between the two groups in CAP or E-value.Conclusion A 12-week per-sonalized exercise intervention can significantly improve weight-related indicators(such as reducing BMI)and body fat composition(such as lowering body fat percentage)in middle-aged and elderly patients with T2DM,in-creased HDL-C,and decreased HbA1c.However,no significant effects were observed on liver lipids content or stiffness,which necessitates further validation through longer-term intervention trials.关键词
运动干预/2型糖尿病/体脂成分/随机对照试验研究Key words
exercise intervention/type 2 diabetes mellitus/body fat composition/randomized controlled trial分类
医药卫生引用本文复制引用
黄少芬,刘嘉紫,宋远凤,施汶言,武晓岩..运动干预对中老年2型糖尿病患者体脂成分和肝脏脂肪的影响:随机对照试验研究[J].遵义医科大学学报,2026,49(3):280-287,8.基金项目
深圳市科技计划资助项目(NO:JCYJ20210324125004013). （NO:JCYJ20210324125004013）
