中国药业2026，Vol.35Issue(7)：1-8,8.DOI:10.3969/j.issn.1006-4931.2026.07.001
万古霉素在不同人群中的药代动力学特征及个体化治疗研究进展
Research Progress of Pharmacokinetic Characteristics and Individualized Therapy of Vancomycin in Different Populations
摘要
Abstract
Objective To provide an evidence-based support for the development of individualized dosing regimens of vancomycin in clinical practice.Methods The recently published population pharmacokinetic studies and related guidelines on vancomycin were systematically analyzed.The research progress on pharmacokinetic characteristics and individualized therapy of vancomycin in different populations such as healthy adults,general inpatients,obese patients,elderly patients,pediatric patients,organ transplant recipients,burn patients,hematological tumor patients,neutropenia patients,and critically ill patients.Results Body mass,renal function,age,and specific disease status are key covariates affecting the pharmacokinetics of vancomycin in vivo.The latest therapeutic drug monitoring guideline recommends using the ratio of the 24-hour area under curve to the minimum inhibitory concentration(AUC0-24h/MIC)as the primary efficacy predictor instead of the traditional practice of trough concentration monitoring.Population pharmacokinetic models combined with Bayesian feedback can more accurately estimate individual pharmacokinetic parameters,thereby optimizing dosing regimens.Conclusion The pharmacokinetic characteristics of vancomycin vary significantly among different populations.Based on therapeutic drug monitoring,individualized dosing strategies guided by population pharmacokinetic models contribute to precise drug therapy and can improve patients'treatment outcomes.关键词
万古霉素/群体药代动力学/不同人群/个体化给药方案/24h血药浓度-时间曲线下面积/最低抑菌浓度/治疗药物监测Key words
vancomycin/population pharmacokinetics/different populations/individualized dosing regimen/AUC0～24 h/MIC/therapeutic drug monitoring分类
医药卫生引用本文复制引用
陈井霞,丁楠,杨云云,王卓..万古霉素在不同人群中的药代动力学特征及个体化治疗研究进展[J].中国药业,2026,35(7):1-8,8.基金项目
国家自然科学基金"青年科学基金"项目[82300017] （）
国家卫生健康委员会医院管理研究所医院药学高质量发展研究课题[NIHAYSZX2546] （）
上海申康医院发展中心诊疗技术推广及优化管理项目[SHDC22025227] （）
上海市医院协会抗菌药物科学化标杆管理项目[2023LCYS001_S04]. （）
