针灸和草药（英文）2026，Vol.6Issue(1)：42-55,14.DOI:10.1097/HM9.0000000000000193
针灸原创理论的科学创新与转化应用研究范式:基于手十二井穴刺激疗法的综述
Research framework for scientific innovation and translational application of original acupuncture theories:a review based on Hand Twelve Jing-Well Points stimulation therapy
摘要
Abstract
The field of acupuncture is currently facing paradigmatic issues,including the difficulty of turning theoretical strengths into technical discourse power,a gap between mechanistic research and clinical imperatives,and the fragmentation of research activities.Therefore,constructing a research paradigm grounded in traditional Chinese medicine theory and validated through contemporary scientific methods is essential.Hand Twelve Jing-Well Points(HTWP)acupuncture,an ancient therapy known for its rapid efficacy and practical application,offers an optimal solution for these challenges.In this study,the theoretical foundations,clinical effectiveness,biological explanations,and Translational applications of HTWP acupuncture were consolidated by integrating a four-step research framework.Initially,we developed the"Well point-Brain Connection"framework rooted in classical theories and informed by the"Root-Knot"concept.Subsequent clinical practice provided evidence of its effectiveness in modulating awareness and facilitating motor-cognitive rehabilitation for patients with central nervous system issues.Moreover,mechanistic research provides scientific verification of a"Sensation-Transmission-Effect"cascade that encompasses the activation of arousal circuits and the repair of the blood-brain barrier.Ultimately,the promotion of translation,standardization of systems,and the use of wearable technologies have aided the transition from passive therapy to proactive health management.This closed-loop concept offers compelling evidence for the"Well point-Brain Connection"and provides an applicable framework for scientific innovation and global distribution of innovative acupuncture hypotheses.关键词
针灸/手十二井穴/中枢神经系统疾病/井-脑相关/研究范式/转化医学Key words
Acupuncture/Central nervous system diseases/Hand Twelve Jing-Well Points/Research paradigm/Translational medicine/Well point-brain connection引用本文复制引用
骆雨,窦报敏,马宁,郭义,徐枝芳,朱征,高菲菲,周丹,李柠岑,吕中茜,周靓,秦思茹,杨元祯..针灸原创理论的科学创新与转化应用研究范式:基于手十二井穴刺激疗法的综述[J].针灸和草药（英文）,2026,6(1):42-55,14.基金项目
This work was supported by the Natural Science Foundation of China(82441053,82074534,82474642) （82441053,82074534,82474642）
The Natural Science Foundation of Jiangxi province(20232BAB206151). （20232BAB206151）
