针灸和草药（英文）2026，Vol.6Issue(1)：119-138,20.DOI:10.1097/HM9.0000000000000194
葛根的植物学特性、化学成分及其治疗代谢性疾病的研究进展
Puerariae Lobatae Radix:botanical traits,chemical constituents,and anti-metabolic disease effects-a review
摘要
Abstract
Puerariae Lobatae Radix(PLR)is a traditional Chinese medicinal herb included in China's inaugural list of substances recognized as both food and medicine.PLR has a long history of use and a wide range of medicinal applications.Its use is associated with a broad range of health-promoting effects.Recent studies have shown that PLR contains abundant bioactive compounds including isoflavones and polysaccharides.These findings demonstrate significant potential for the prevention and treatment of metabolic diseases(MDs).The potential mechanisms underlying these effects involve several targets and pathways,including activation of the phosphoinositide 3-kinase/protein kinase B(PI3K/Akt)and AMPK signaling pathways;regulation of key factors,such as peroxisome proliferator-activated receptors;and modulation of the gut microbiota composition.This systematic review examines the botanical characteristics and primary chemical constituents of PLR,with particular emphasis on recent research advances,mechanisms of action,and the clinical applications of its active components in MDs intervention.This review aims to provide theoretical guidance for further development,quality improvement,and application of PLR in the prevention and treatment of MDs.关键词
葛根/植物学特征/化学成分/代谢性疾病/临床应用Key words
Botanical characteristics/Chemical constituents/Clinical applications/Metabolic diseases/Puerariae Lobatae Radix引用本文复制引用
陈新滔,孟晓伟,Olga Maria Duarte Silva,吴波,管咏梅,张继稳,朱卫丰,张妮,吴文婷,刘婧,李琼,臧振中,欧阳辉,董欢欢,周旭..葛根的植物学特性、化学成分及其治疗代谢性疾病的研究进展[J].针灸和草药（英文）,2026,6(1):119-138,20.基金项目
This study was supported by the Development of a Major Chinese Herbal Medicine Species,Pueraria mon-tana(Lour.).Merr(Pueraria lobata,Puerariae thom-sonii)(2017YFC1702900),the Key R&D Program of Jiangxi Province(20224BBG71023),the National Key R&D Program(2024YFE0104600),and the National Administration of Traditional Chinese Medicine Project(GZY-KJS-2023-033). （Lour.）
