首页|期刊导航|癌症生物学与医学（英文版）|Expert consensus on the detection and clinical application of tumor mutational burden

Expert consensus on the detection and clinical application of tumor mutational burden

Zhenying Guo Xueping Xiang Peng Luo Weiwei Pan Fei Pang Fan Wu Dejian Gu Li Wang Liping Wang Youcai Zhu Li Lin Weiwen Li Jing Zhao Xinqing Lin Jing Cai Ling Xu Jisheng Li Xiaodong Jiao Kainan Li Jia Wei Huijing Feng Lin Wang Yingying Du Huanwen Wu Wang Yao Xuefei Shi Xiaomin Niu Dongmei Yuan Yanwen Yao Yinbin Zhang Binbin Song Wenfeng Li Jianfei Fu Hong Wang Weixing Li Mingxiang Ye Dong Wang Zhaofeng Wang Qing Ji Yuan Fang Qing Wei Zhen Wang Bin Wan Donglai Lv Xiaofeng Li Jinpu Yu Shengjie Yang Jing Kang Jiatao Zhang Chao Zhang Lin Shi Yina Wang Bihui Li Zhang Zhang Ke Wang Zhefeng Liu Jingping Yuan Nong Yang Lin Wu Xiaobing Chen Gu Jin Zhongwu Li Miao Li Guansong Wang Jiandong Wang Meiyu Fang Yong Fang Shuangshuang Wang Xiaojia Wang Jing Chen Yiping Zhang Xixu Zhu Yi Shen Shenglin Ma Biyun Wang Lu Si Yong Song Yuanzhi Lu Cong Wang Aijun Liu Yuchen Han Yun Gu Bingjian Lv Chunwei Xu Liping Zhang Yueping Liu Xiaobin Cui Weizhong Gu Yining Li Wei Wang Wenjun Yang Weiguo Long Jingjing Xiang Hong Mou Shirong Zhang Biao Liu Huajuan Ruan Yubin Wang Yongjie Zhu Feng Wang Zhonghua Wang Xiaomin Feng Xing Liu Peng Li Min Deng Yue Hao Bin Lian Lili Mao Qian Wang Wenxian Wang Zhengbo Song Ziming Li Wenzhao Zhong Zhijie Wang Shengxiang Ren Wenfeng Fang Xiaotong Hu Yongchang Zhang Jingjing Liu Xiuyu Cai Anwen Liu Wen Li Ping Zhan Hongbing Liu Tangfeng Lv Liyun Miao Lingfeng Min Ming Zhao Yu Chen Yu Zhang Zhansheng Jiang Gen Lin Long Huang Xingxiang Pu Rongbo Lin Weifeng Liu Chuangzhou Rao Chan Xiang Dongqing Lv Zongyang Yu Peng Shen Xiaoyan Li Chuanhao Tang Chengzhi Zhou Junping Zhang Junli Xue Hui Guo Qian Chu Yingshi Piao Rui Meng Jingxun Wu Rui Zhang Jin Zhou Zhengfei Zhu Yongheng Li Hong Qiu Fan Xia Yuanyuan Lu Xiaofeng Chen Pingli Sun Rui Ge Enyong Dai Yu Han Jian Zhang Yinghua Ji Xianbin Liang Hongmei Zhang Xuelei Ma Xuewen Liu Yu Yao

癌症生物学与医学（英文版）2026，Vol.23Issue(2)：218-246,29.

癌症生物学与医学（英文版）2026，Vol.23Issue(2)：218-246,29.DOI:10.20892/j.issn.2095-3941.2025.0351

Expert consensus on the detection and clinical application of tumor mutational burden

Zhenying Guo ¹Xueping Xiang ²Peng Luo ³Weiwei Pan ⁴Fei Pang ⁵Fan Wu ⁶Dejian Gu ⁷Li Wang ⁷Liping Wang ⁸Youcai Zhu ⁹Li Lin ¹⁰Weiwen Li ¹¹Jing Zhao ¹²Xinqing Lin ¹³Jing Cai ¹⁴Ling Xu ¹⁵Jisheng Li ¹⁶Xiaodong Jiao ¹⁷Kainan Li ¹⁸Jia Wei ¹⁹Huijing Feng ²⁰Lin Wang ²¹Yingying Du ²²Huanwen Wu ²³Wang Yao ²⁴Xuefei Shi ²⁵Xiaomin Niu ²⁶Dongmei Yuan ²⁷Yanwen Yao ²⁷Yinbin Zhang ²⁸Binbin Song ²⁹Wenfeng Li ³⁰Jianfei Fu ³¹Hong Wang ³²Weixing Li ³³Mingxiang Ye ²⁷Dong Wang ²⁷Zhaofeng Wang ²⁷Qing Ji ³⁴Yuan Fang ³⁵Qing Wei ³⁴Zhen Wang ³⁶Bin Wan ³⁷Donglai Lv ³⁸Xiaofeng Li ⁹Jinpu Yu ³⁹Shengjie Yang ⁴⁰Jing Kang ⁴¹Jiatao Zhang ⁴¹Chao Zhang ⁴¹Lin Shi ⁴²Yina Wang ⁴³Bihui Li ⁴⁴Zhang Zhang ⁴⁵Ke Wang ⁴⁶Zhefeng Liu ³²Jingping Yuan ⁴⁷Nong Yang ⁴⁸Lin Wu ⁴⁹Xiaobing Chen ⁵⁰Gu Jin ⁵¹Zhongwu Li ⁵²Miao Li ⁵³Guansong Wang ⁵⁴Jiandong Wang ⁵⁵Meiyu Fang ³⁴Yong Fang ⁵⁶Shuangshuang Wang ⁵⁷Xiaojia Wang ³⁴Jing Chen ⁵⁸Yiping Zhang ³⁴Xixu Zhu ³⁶Yi Shen ⁵⁹Shenglin Ma ⁶⁰Biyun Wang ⁶¹Lu Si ⁶²Yong Song ²⁷Yuanzhi Lu ⁶³Cong Wang ⁶⁴Aijun Liu ⁶⁵Yuchen Han ⁶⁶Yun Gu ⁶⁷Bingjian Lv ⁶⁸Chunwei Xu ⁶⁹Liping Zhang ⁷⁰Yueping Liu ⁷¹Xiaobin Cui ⁷²Weizhong Gu ⁷³Yining Li ⁷⁴Wei Wang ⁷⁵Wenjun Yang ⁷⁶Weiguo Long ⁷⁷Jingjing Xiang ⁷⁸Hong Mou ⁷⁹Shirong Zhang ⁸⁰Biao Liu ⁸¹Huajuan Ruan ⁸²Yubin Wang ⁸³Yongjie Zhu ⁸⁴Feng Wang ⁸⁵Zhonghua Wang ⁸⁶Xiaomin Feng ⁶⁷Xing Liu ⁸⁷Peng Li ⁸⁸Min Deng ⁸⁹Yue Hao ³⁴Bin Lian ⁶²Lili Mao ⁶²Qian Wang ⁹⁰Wenxian Wang ³⁴Zhengbo Song ³⁴Ziming Li ²⁶Wenzhao Zhong ⁴¹Zhijie Wang ⁹¹Shengxiang Ren ⁹²Wenfeng Fang ⁹³Xiaotong Hu ⁹⁴Yongchang Zhang ⁴⁸Jingjing Liu ⁹⁵Xiuyu Cai ⁹⁶Anwen Liu ¹⁴Wen Li ⁹⁷Ping Zhan ²⁷Hongbing Liu ²⁷Tangfeng Lv ²⁷Liyun Miao ⁹⁸Lingfeng Min ⁹⁹Ming Zhao ¹⁰⁰Yu Chen ¹⁰¹Yu Zhang ¹⁰²Zhansheng Jiang ¹⁰³Gen Lin ¹⁰¹Long Huang ¹⁴Xingxiang Pu ⁴⁹Rongbo Lin ¹⁰¹Weifeng Liu ¹⁰⁴Chuangzhou Rao ¹⁰⁵Chan Xiang ⁶⁶Dongqing Lv ¹⁰⁶Zongyang Yu ¹⁰⁷Peng Shen ¹⁰⁸Xiaoyan Li ¹⁰⁹Chuanhao Tang ¹⁰Chengzhi Zhou ¹³Junping Zhang ²⁰Junli Xue ¹¹⁰Hui Guo ²⁸Qian Chu ¹¹¹Yingshi Piao ¹¹²Rui Meng ⁵⁸Jingxun Wu ¹¹³Rui Zhang ¹¹⁴Jin Zhou ¹¹⁵Zhengfei Zhu ¹¹⁶Yongheng Li ¹¹⁷Hong Qiu ¹¹¹Fan Xia ¹¹⁶Yuanyuan Lu ¹¹⁸Xiaofeng Chen ¹¹⁹Pingli Sun ¹²⁰Rui Ge ¹²¹Enyong Dai ¹²²Yu Han ¹²³Jian Zhang ³Yinghua Ji ¹²⁴Xianbin Liang ¹²⁵Hongmei Zhang ¹²⁶Xuelei Ma ¹²⁶Xuewen Liu ¹²⁷Yu Yao¹²⁸

作者信息

1. Cancer Center,Department of Pathology,Zhejiang Provincial People's Hospital(Affiliated People's Hospital),Hangzhou Medical College,Hangzhou 310014,China
2. Department of Pathology,The Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310009,China
3. Department of Oncology,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China
4. Department of Cell Biology,College of Medicine,Jiaxing University,Jiaxing 314001,China
5. Department of Medical,Shanghai OrigiMed Co,Ltd,Shanghai 201114,China
6. Department of Medical,Menarini Silicon Biosystems SpA,Shanghai 200333,China
7. Department of Medical,Geneplus-Beijing,Beijing 102200,China
8. Department of Oncology,Baotou Cancer Hospital,Baotou 014000,China
9. Department of Thoracic Disease Diagnosis and Treatment Center,Zhejiang Rongjun Hospital,The Third Affiliated Hospital of Jiaxing University,Jiaxing 314000,China
10. Department of Medical Oncology,Peking University International Hospital,Beijing 102206,China
11. Department of Oncology,Lishui Municipal Central Hospital,Lishui 323000,China
12. Department of Pathology,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,China
13. State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510300,China
14. Department of Oncology,Second Affiliated Hospital of Nanchang University,Nanchang 330006,China
15. Department of Interventional Pulmonary Diseases,Anhui Chest Hospital,Hefei 230011,China
16. Department of Medical Oncology,Qilu Hospital,Cheeloo College of Medicine,Shandong University,Jinan 250012,China
17. Department of Medical Oncology,Shanghai Changzheng Hospital,Naval Medical University,Shanghai 200070,China
18. Department of Oncology,Shandong Provincial Third Hospital,Cheeloo College of Medicine,Shandong University,Jinan 250031,China
19. Department of The Comprehensive Cancer Center,Affiliated Drum Tower Hospital,Medical School of Nanjing University,Nanjing 210008,China
20. Department of Thoracic Oncology,Shanxi Academy of Medical Sciences,Shanxi Bethune Hospital,Taiyuan 030032,China
21. Department of Pathology,Shanxi Academy of Medical Sciences,Shanxi Bethune Hospital,Taiyuan 030032,China
22. Department of Oncology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China
23. Department of Pathology,Peking Union Medical College Hospital,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100730,China
24. Department of Interventional Oncology,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510060,China
25. Department of Respiratory Medicine,Huzhou Hospital,Zhejiang University School of Medicine,Huzhou 313000,China
26. Department of Shanghai Lung Cancer Center,Shanghai Chest Hospital,Shanghai Jiao Tong University,Shanghai 200030,China
27. Department of Respiratory Medicine,Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,China
28. Department of Oncology,The Second Affiliated Hospital of Medical College,Xi'an Jiaotong University,Xi'an 710004,China
29. Department of Medical Oncology,The Affiliated Hospital of Jiaxing University,Jiaxing 314000,China
30. Department of Radiation Oncology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China
31. Department of Medical Oncology,Affiliated Jinhua Hospital,Zhejiang University School of Medicine,Jinhua 321000,China
32. Senior Department of Oncology,The 5th Medical Center of PLA General Hospital,Beijing 100071,China
33. Laboratory Medicine Center,Zhejiang Center for Clinical Laboratory,Zhejiang Provincial People's Hospital,Affiliated People's Hospital,Hangzhou Medical College,Hangzhou 310014,China
34. Department of Chemotherapy,Chinese Academy of Sciences University Cancer Hospital(Zhejiang Cancer Hospital),Hangzhou 310022,China
35. Department of Pathology,Anhui Provincial Children's Hospital,Hefei 230051,China
36. Department of Radiation Oncology,Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,China
37. Department of Respiratory Medicine,The Affiliated Jiangning Hospital of Nanjing Medical University,Nanjing 210002,China
38. Department of Clinical Oncology,The 901 Hospital of Joint Logistics Support Force of People Liberation Army,Hefei 230031,China
39. Department of Cancer Molecular Diagnostics Core,Tianjin Medical University Cancer Institute and Hospital,Tianjin 300060,China
40. Department of Thoracic Surgery,Chuxiong Yi Autonomous Prefecture People's Hospital,Chuxiong 675000,China
41. Guangdong Lung Cancer Institute,Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,School of Medicine,Guangzhou 510080,China
42. Department of Respiratory Medicine,Zhongshan Hospital,Fudan University,Shanghai 200032,China
43. Department of Oncology,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310000,China
44. Department of Oncology,The Second Affiliated Hospital of Guilin Medical University,Guilin 541199,China
45. International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education(MOE),Guangzhou City Key Laboratory of Precision Chemical Drug Development,School of Pharmacy,Jinan University,Guangzhou 510632,China
46. National Health Commission(NHC)Key Laboratory of Nuclear Medicine,Jiangsu Key Laboratory of Molecular Nuclear Medicine,Jiangsu Institute of Nuclear Medicine,Wuxi 214063,China||Department of Radiopharmaceuticals,School of Pharmacy,Nanjing Medical University,Nanjing 210000,China
47. Department of Pathology,Renmin Hospital of Wuhan University,Wuhan 430060,China
48. Department of Medical Oncology,Lung Cancer and Gastrointestinal Unit,Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha 410013,China
49. The Second Department of Thoracic Oncology,Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha 410013,China
50. Department of Oncology,The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer Hospital,Zhengzhou 450008,China
51. Department of Bone and Soft-tissue Surgery,Chinese Academy of Sciences University Cancer Hospital(Zhejiang Cancer Hospital),Hangzhou 310022,China
52. Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Department of Pathology,Peking University Cancer Hospital&Institute,Beijing 100142,China
53. Department of Oncology,The Cancer Hospital of Qinghai Province,Xining 810001,China
54. Institute of Respiratory Diseases,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China
55. Department of Pathology,Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,China
56. Department of Medical Oncology,Sir Run Run Shaw Hospital,Zhejiang University,Hangzhou 310016,China
57. Department of Pathology,Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Province Hospital of Chinese Medicine,Nanjing 210029,China
58. Cancer Center,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China
59. Department of Thoracic Surgery,Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,China
60. Department of Oncology,Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province,Affiliated Hangzhou Cancer Hospital,Cancer Center,Westlake University School of Medicine,Hangzhou 310006,China
61. Department of Breast Cancer and Urological Medical Oncology,Fudan University Shanghai Cancer Center,Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China
62. Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Department of Melanoma and Sarcoma,Peking University Cancer Hospital&Institute,Beijing 100142,China
63. Department of Clinical Pathology,The First Affiliated Hospital of Jinan University,Guangzhou 510630,China
64. Department of Pathology,The First Affiliated Hospital of Nanjing Medical University(Jiangsu Province Hospital),Nanjing 210029,China
65. Senior Department of Pathology,the 7th Medical Center of PLA General Hospital,Beijing 100700,China
66. Department of Pathology,Shanghai Chest Hospital,Shanghai Jiao Tong University,Shanghai 200030,China
67. Department of Pathology,Women's Hospital of Nanjing Medical University,Nanjing Women and Children's Healthcare Hospital,Nanjing 210004,China
68. Department of Surgical Pathology Women's Hospital,School of Medicine,Zhejiang University,Hangzhou 310006,of China
69. Hangzhou Institute of Medicine(HIM),Chinese Academy of Sciences,Hangzhou 310022,China
70. Department of Pathology,Shanghai Pudong Hospital,School of Medicine,Fudan University,Shanghai 201399,China
71. Department of Pathology,The Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China
72. Department of Pathology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China
73. Department of Pathology,Children's Hospital Zhejiang University School of Medicine,Hangzhou 310005,China
74. Department of Pathology,Stomatology Hospital,School of Stomatology,Zhejiang University,Hangzhou 310000,China
75. Department of Pathology,Tongde Hospital of Zhejiang Province,Hangzhou 310012,China
76. Department of Pathology,Affiliated Hospital of Hangzhou Normal University,Hangzhou 310000,China
77. Department of Pathology,The People's Hospital of Leshan,Leshan 614000,China
78. Department of Pathology,Affiliated Hangzhou First People's Hospital,Westlake University School of Medicine,Hangzhou 310006,China
79. Department of Pathology,Chun'an First People's Hospital,Hangzhou 311700,China
80. Translational Medicine Research Center,Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province,Affiliated Hangzhou First People's Hospital,Cancer Center,Westlake University School of Medicine,Hangzhou 310006,China
81. Department of Pathology,The Affiliated Suzhou Hospital,Nanjing Medical University,Suzhou 215006,China
82. Department of Pathology,The First People's Hospital of Hangzhou Lin'an District,Affiliated Lin'an People's Hospital,Hangzhou Medical College,Hangzhou 311300,China
83. Department of Pathology,Tiantai County People's Hospital,Taizhou 317200,China
84. Department of Pathology,First People's Hospital of Aksu,Aksu 843000,China
85. Department of Pathology,Xianju People's Hospital,Zhejiang Southeast Campus of Zhejiang Provincial People's Hospital,Affiliated Xianju's Hospital,Hangzhou Medical College,Taizhou 317300,China
86. Department of Pathology,Dinghai Branch of Zhejiang Provincial People's Hospital,Zhoushan 316000,China
87. Department of Pathology,Shulan(Hangzhou)Hospital,Hangzhou 310022,China
88. Department of Pathology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China
89. Department of Pathology,Zhejiang Provincial People's Hospital(Fuyang Campus),Hangzhou 311400,China
90. Department of Respiratory Medicine,Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Province Hospital of Chinese Medicine,Nanjing 210029,China
91. State Key Laboratory of Molecular Oncology,Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China
92. Department of Medical Oncology,Shanghai Pulmonary Hospital,School of Medicine,Tongji University,Shanghai 200433,China
93. Department of Medical Oncology,Sun Yat-sen University Cancer Center,State Key Laboratory of Oncology in South China,Collaborative Innovation Center for Cancer Medicine,Guangzhou 510060,China
94. Department of Pathology,Sir Run Run Shaw Hospital,Zhejiang University,Hangzhou 310016,China
95. Department of Thoracic Cancer,Jilin Cancer Hospital,Changchun 130012,China
96. Department of VIP Inpatient,Sun Yat-Sen University Cancer Center,State Key Laboratory of Oncology in South China,Collaborative Innovation Center for Cancer Medicine,Guangzhou 510060,China
97. Key Laboratory of Respiratory Disease of Zhejiang Province,Department of Respiratory and Critical Care Medicine,Second Affiliated Hospital of Zhejiang University School of Medicine,Cancer Center,Zhejiang University,Hangzhou 310009,China
98. Department of Respiratory Medicine,Affiliated Drum Tower Hospital,Medical School of Nanjing University,Nanjing 210008,China
99. Department of Respiratory Medicine,Clinical Medical School of Yangzhou University,Subei People's Hospital of Jiangsu Province,Yangzhou 225001,China
100. Ningbo Clinical Pathology Diagnosis Center,Ningbo 315100,China
101. Department of Medical Oncology,Fujian Medical University Cancer Hospital&Fujian Cancer Hospital,Fuzhou 350014,China
102. Department of Oncology,Guizhou Provincial People's Hospital,Guiyang 550001,China
103. Department of Integrative Oncology,Tianjin Medical University Cancer Institute and Hospital,Tianjin 300060,China
104. Department of Orthopedic Oncology Surgery,Beijing Ji shui tan Hospital,Peking University,Beijing 100035,China
105. Department of Radiotherapy and Chemotherapy,Hwamei Hospital,University of Chinese Academy of Sciences,Ningbo 315010,China
106. Department of Pulmonary Medicine,Taizhou Hospital of Wenzhou Medical University,Taizhou 317000,China
107. Department of Respiratory Medicine,the 900th Hospital of the Joint Logistics Team(the Former Fuzhou General Hospital),Fujian Medical University,Fuzhou 350025,China
108. Department of Oncology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China
109. Department of Oncology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100700,China
110. Department of Oncology,Shanghai East Hospital,School of Medicine,Tongji University,Shanghai 200123,China
111. Department of Oncology,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
112. Department of Pathology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China
113. Department of Medical Oncology,The First Affiliated Hospital of Medicine,Xiamen University,Xiamen 361003,China
114. Department of Medical Oncology,Cancer Hospital of China Medical University,Shenyang 110042,China
115. Department of Medical Oncology,Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,School of Medicine,University of Electronic Science and Technology,Chengdu 610041,China
116. Department of Radiation Oncology,Fudan University Shanghai Cancer Center,Shanghai 200032,China
117. Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Department of Radiation Oncology,Peking University Cancer Hospital&Institute,Beijing 100142,China
118. State Key Laboratory of Cancer Biology,National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases,Fourth Military Medical University,Xi'an 710032,China
119. Department of Oncology,Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital,Nanjing 210029,China
120. Department of Pathology,The Second Hospital of Jilin University,Changchun 130041,China
121. Department of General Surgery,Huadong Hospital Affiliated to Fudan University,Shanghai 200040,China
122. Department of Oncology and Hematology,China-Japan Union Hospital of Jilin University,Changchun 130033,China
123. Department of Gastrointestinal Oncology,Harbin Medical University Cancer Hospital,Harbin 150081,China
124. Department of Oncology,The First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453000,China
125. Department of Oncology,The Third People's Hospital of Zhengzhou,Zhengzhou 450000,China
126. Department of Biotherapy,State Key Laboratory of Biotherapy,Cancer Center,West China Hospital,Sichuan University,Chengdu 610041,China
127. Department of Oncology,the Third Xiangya Hospital,Central South University,Changsha 410013,China
128. Department of Medical Oncology,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China
折叠

摘要

关键词

Biomarkers/tumor mutational burden/tumor immunotherapy/targeted panel sequencing/whole-exome sequencing

Key words

Biomarkers/tumor mutational burden/tumor immunotherapy/targeted panel sequencing/whole-exome sequencing

引用本文复制引用

Zhenying Guo,Xueping Xiang,Peng Luo,Weiwei Pan,Fei Pang,Fan Wu,Dejian Gu,Li Wang,Liping Wang,Youcai Zhu,Li Lin,Weiwen Li,Jing Zhao,Xinqing Lin,Jing Cai,Ling Xu,Jisheng Li,Xiaodong Jiao,Kainan Li,Jia Wei,Huijing Feng,Lin Wang,Yingying Du,Huanwen Wu,Wang Yao,Xuefei Shi,Xiaomin Niu,Dongmei Yuan,Yanwen Yao,Yinbin Zhang,Binbin Song,Wenfeng Li,Jianfei Fu,Hong Wang,Weixing Li,Mingxiang Ye,Dong Wang,Zhaofeng Wang,Qing Ji,Yuan Fang,Qing Wei,Zhen Wang,Bin Wan,Donglai Lv,Xiaofeng Li,Jinpu Yu,Shengjie Yang,Jing Kang,Jiatao Zhang,Chao Zhang,Lin Shi,Yina Wang,Bihui Li,Zhang Zhang,Ke Wang,Zhefeng Liu,Jingping Yuan,Nong Yang,Lin Wu,Xiaobing Chen,Gu Jin,Zhongwu Li,Miao Li,Guansong Wang,Jiandong Wang,Meiyu Fang,Yong Fang,Shuangshuang Wang,Xiaojia Wang,Jing Chen,Yiping Zhang,Xixu Zhu,Yi Shen,Shenglin Ma,Biyun Wang,Lu Si,Yong Song,Yuanzhi Lu,Cong Wang,Aijun Liu,Yuchen Han,Yun Gu,Bingjian Lv,Chunwei Xu,Liping Zhang,Yueping Liu,Xiaobin Cui,Weizhong Gu,Yining Li,Wei Wang,Wenjun Yang,Weiguo Long,Jingjing Xiang,Hong Mou,Shirong Zhang,Biao Liu,Huajuan Ruan,Yubin Wang,Yongjie Zhu,Feng Wang,Zhonghua Wang,Xiaomin Feng,Xing Liu,Peng Li,Min Deng,Yue Hao,Bin Lian,Lili Mao,Qian Wang,Wenxian Wang,Zhengbo Song,Ziming Li,Wenzhao Zhong,Zhijie Wang,Shengxiang Ren,Wenfeng Fang,Xiaotong Hu,Yongchang Zhang,Jingjing Liu,Xiuyu Cai,Anwen Liu,Wen Li,Ping Zhan,Hongbing Liu,Tangfeng Lv,Liyun Miao,Lingfeng Min,Ming Zhao,Yu Chen,Yu Zhang,Zhansheng Jiang,Gen Lin,Long Huang,Xingxiang Pu,Rongbo Lin,Weifeng Liu,Chuangzhou Rao,Chan Xiang,Dongqing Lv,Zongyang Yu,Peng Shen,Xiaoyan Li,Chuanhao Tang,Chengzhi Zhou,Junping Zhang,Junli Xue,Hui Guo,Qian Chu,Yingshi Piao,Rui Meng,Jingxun Wu,Rui Zhang,Jin Zhou,Zhengfei Zhu,Yongheng Li,Hong Qiu,Fan Xia,Yuanyuan Lu,Xiaofeng Chen,Pingli Sun,Rui Ge,Enyong Dai,Yu Han,Jian Zhang,Yinghua Ji,Xianbin Liang,Hongmei Zhang,Xuelei Ma,Xuewen Liu,Yu Yao..Expert consensus on the detection and clinical application of tumor mutational burden[J].癌症生物学与医学（英文版）,2026,23(2):218-246,29.

基金项目

This research was supported by grants from the National Natural Science Foundation of China(Grant No.82072577)and from the International Medical Association(Grant No.IMA-F-2025-001). （Grant No.82072577）

癌症生物学与医学（英文版）

ISSN：2095-3941

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