肿瘤防治研究2026，Vol.53Issue(3)：176-186,11.DOI:10.3971/j.issn.1000-8578.2026.25.0705
槐耳通过改善肠道菌群增强奥沙利铂对胃癌的疗效
Huaier Enhances Efficacy of Oxaliplatin in Treatment of Gastric Cancer by Improving Gut Microbiota
摘要
Abstract
Objective To elucidate the changes in the gut microbiota and molecular mechanism of huaier in enhancing the efficacy of oxaliplatin(OXA)chemotherapy in gastric cancer(GC).Methods The effects of huaier on the gut microbiota structure and intestinal barrier function in MKN45-bearing mice were analyzed by using 16S rRNA sequencing,RT-qPCR,and IHC.UPLC-MS and network pharmacology,as well as in vivo experimental approaches,were employed to investigate the key bioactive constituents of huaier systema-tically and elucidate the underlying mechanisms by which huaier exerts therapeutic effects against GC.The expression of the PI3K/AKT/SREBP pathway was detected in cancer cells and tissues via Western blot analysis.The safety profile of huaier combined with OXA was verified through serum bioche-mistry and HE-stained tissue section analyses.Results Hua-ier inhibited the PI3K/AKT/SREBP pathway by increasing the abundance of Akkermansia muciniphila,reduced lipid droplet deposition,and ultimately enhanced the sensitivity to OXA in the treatment of GC.Conclusion This study demonstrates the value of huaier in gastric cancer treatment by enhancing chemosensitivity and provides novel insights into its systemic therapeutic effects through molecular mechanisms and gut microbiota modulation.关键词
槐耳/胃癌/PI3K/AKT/SREBP通路/肠道菌群/肠道屏障Key words
Huaier/Gastric cancer/PI3K/AKT/SREBP path-way/Gut microbiota/Intestinal barrier分类
医药卫生引用本文复制引用
张胜莲,王瑞智,高玉亭,张桓虎,石新丽,杜智敏,龚艺,兰美琦,刘萍,熊亚军,公艳丽,宋晓永,李俊丽..槐耳通过改善肠道菌群增强奥沙利铂对胃癌的疗效[J].肿瘤防治研究,2026,53(3):176-186,11.基金项目
国家自然科学基金(82072740) （82072740）
山西省基础研究计划(202403021221199) （202403021221199）
山西中医药大学高层次引进人才科研启动基金(2023RC03) The National Natural Science Foundation of China(No.82072740) （2023RC03）
The Fundamental Research Program of Shan-xi Province(No.202403021221199) （No.202403021221199）
The Foundation for High-level Talents of Shanxi University of Chinese Medicine(No.2023RC03) （No.2023RC03）
