肿瘤防治研究2026，Vol.53Issue(3)：194-202,9.DOI:10.3971/j.issn.1000-8578.2026.25.0826
CEACAM6表达与食管鳞癌免疫浸润及不良预后的关联
CEACAM6 Expression is Associated with Immune Infiltration and Poor Prognosis in Esophageal Squamous Cell Carcinoma
摘要
Abstract
Objective To investigate the expression of carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)in esophageal squamous cell carcinoma(ESCC)and analyze its correlation with immune cell infiltration and patient prognosis.Methods Three ESCC datasets(GSE161533,GSE26886,and GSE23400)from the GEO database were analyzed to identify differentially expressed genes.CEACAM6 was identified as a key gene through survival analysis.Its expression,prognostic value,and relationship with immune cell infiltration were further explored using databases,such as TIMER.Tissue samples were collected from 162 patients with ESCC.Immunohistochemistry was performed to detect the expression of CEACAM6,immune cell markers(CD4,CD8,CD20,and CD56),and immune checkpoint molecules(HHLA2 and CD40LG).Correlations between CEACAM6 expression and clinicopathological features,immune cell infiltration,and immune checkpoints were analyzed.Results Bioinformatic analysis and clinical sample validation confirmed that CEACAM6 expression was significantly upregulated in ESCC tissues compared with adjacent nontumor tissues(P<0.05).High CEACAM6 expression was closely associated with advanced clinical stage(AJCC Ⅲ-Ⅳ),high T stage(T3-T4),lymph node metastasis,nonulcerative type,and poor prognosis.Furthermore,CEACAM6 expression levels were positively correlated with the infiltration density of CD8+T cells,CD4+T cells,and CD20+B cells within the tumor microenvir-onment and with the expression of the immune checkpoint molecules HHLA2 and CD40LG(all P<0.05).Conclusion CEACAM6 serves as an independent poor prognostic factor for ESCC.Its high expression is implicated in the modulation of the tumor immune microenvironment by correlating with specific immune cell infiltration and immune checkpoint molecules,suggesting its potential as a novel prognostic biomarker and immunotherapeutic target for ESCC.关键词
CEACAM6/食管鳞状细胞癌/肿瘤微环境/预后/免疫浸润Key words
CEACAM6/Esophageal squamous cell carcinoma/Tumor microenvironment/Prognosis/Immune infiltration分类
医药卫生引用本文复制引用
李家辉,徐恩伟,崔巍,赵园园,康克清,步鹏,赵国海,周扬..CEACAM6表达与食管鳞癌免疫浸润及不良预后的关联[J].肿瘤防治研究,2026,53(3):194-202,9.基金项目
National Natural Science Foundation of China(No.82172659) （No.82172659）
Shanxi Province Basic Research Program(No.202203021222386) （No.202203021222386）
Project of Shanxi Provincial Health Commission(No.2022117) （No.2022117）
Science and Education Cultivation Fund of the National Cancer Regional Medical Center,Shanxi Provincial Cancer Hospital(Nos.BD2023006,QH2023007) 国家自然科学基金(82172659) （Nos.BD2023006,QH2023007）
山西省基础研究计划(202203021222386) （202203021222386）
山西省卫生健康委员会项目(2022117) （2022117）
山西省肿瘤医院国家癌症区域医学中心科教培育基金(BD2023006,QH2023007) （BD2023006,QH2023007）
