肿瘤防治研究2026，Vol.53Issue(3)：211-218,8.DOI:10.3971/j.issn.1000-8578.2026.25.0658
基于NF-κB信号通路探讨中药治疗肝癌的研究进展
Research Progress on Treatment of Liver Cancer with Mechanistic Insights into Herbal Medicine:Focus on NF-κB Signaling Pathway
摘要
Abstract
Liver cancer ranks among malignancies with high global incidence and mortality rates,presenting significant therapeutic challenges.The NF-κB signaling pathway plays a pivotal role in pathogenesis,progression,and treatment of liver cancer,where its aberrant activation is intricately linked to tumor cell proliferation and the dysregulation of apoptosis.In recent years,targeting the inhibition of this pathway has become an important research direction in the treatment of liver cancer.Traditional Chinese medicine(TCM),characterized by multicomponent nature and multitarget effects,exhibits unique advantages in the management of liver cancer.In this article,the regulatory mechanisms of the NF-κB signaling pathway in liver cancer are systematically reviewed,and the research progress on how TCM exerts antitumor effects by inhibiting this pathway and inducing apoptosis in liver cancer cells is summarized.This work provides a theoretical basis and new insights for the study of single compounds and compound formulations of TCM against liver cancer.关键词
NF-κB信号通路/中药/肝癌/细胞凋亡/多靶点治疗Key words
NF-κB signaling pathway/Traditional Chinese medicine/Liver cancer/Apoptosis/Multi-target therapy分类
医药卫生引用本文复制引用
黄恬锞,谢爱泽..基于NF-κB信号通路探讨中药治疗肝癌的研究进展[J].肿瘤防治研究,2026,53(3):211-218,8.基金项目
National Integrated Traditional Chinese and Western Medicine"Flagship"Department Construction Project(No.[2024]221 issued by the Department of Integrated Traditional Chinese and Western Medicine,National Administration of Traditional Chinese Medicine) 国家中西医协同"旗舰"科室建设项目(国中医药综结合函[2024]221号) （No.[2024]221 issued by the Department of Integrated Traditional Chinese and Western Medicine,National Administration of Traditional Chinese Medicine）
