肿瘤防治研究2026，Vol.53Issue(3)：219-225,7.DOI:10.3971/j.issn.1000-8578.2026.25.0666
CKIP-1在肿瘤免疫微环境中的功能及其作用机制研究进展
Research Progress on Role and Mechanism of CKIP-1 in Tumor Immune Micro-environment
摘要
Abstract
Casein kinase 2-interacting protein-1(CKIP-1)is a multifunctional scaffold protein with a pleckstrin homology domain.Its dynamic subcellular localization enables dual roles in tumor progression,"promoting"or"suppressing"malignancy by regulating immune metabolism and signaling networks within the tumor immune microenvironment(TIME).This review synthesizes current knowledge on CKIP-1's structural characteristics and TIME regulatory mechanisms.We highlight that CKIP-1 inhibits macrophage M2 polarization,antagonizes Smurf1-mediated oncoprotein ubiquitination,and modulates key pathways,including TGF-β and PI3K/AKT.Targeting CKIP-1 enhances the efficacy of immune checkpoint inhibitors and CAR-T therapy,but clinical translation faces challenges,such as unclear tissue-specific mechanisms and combination toxicity.This review aims to synthesize the regulatory functions of CKIP-1 in the tumor immune microenvironment,thereby offering a theoretical basis for precision immunotherapy targeting CKIP-1 and further analyzing its dynamic mechanisms to advance clinical applications.关键词
CKIP-1/肿瘤免疫微环境/Smurf1/免疫逃避/免疫治疗Key words
CKIP-1/Tumor immune microenvironment/Smurf1/Immune evasion/Immunotherapy分类
医药卫生引用本文复制引用
曹真文,吉茹..CKIP-1在肿瘤免疫微环境中的功能及其作用机制研究进展[J].肿瘤防治研究,2026,53(3):219-225,7.基金项目
High-level Clinical Specialty Construction Science and Technology Project of Peking University Cancer Hospital,Inner Mongolia Branch(No.2024YNYB003) （No.2024YNYB003）
Sub-project of High-level Clinical Specialty Development Science and Technology Project of Public Hospitals in Inner Mongolia Autonomous Region(No.2023SGGZ072) 北京大学肿瘤医院内蒙古医院高水平临床专科建设科技项目(2024YNYB003) （No.2023SGGZ072）
内蒙古自治区公立医院高水平临床专科发展科技项目(2023SGGZ072) （2023SGGZ072）
