肿瘤防治研究2026，Vol.53Issue(3)：226-232,7.DOI:10.3971/j.issn.1000-8578.2026.25.0795
免疫治疗时代下炎症营养指标对鼻咽癌的预后预测价值研究进展
Research Progress on Predictive Value of Inflammatory and Nutritional Indicators for Prognosis of Nasopharyngeal Carcinoma in the Era of Immunotherapy
摘要
Abstract
Nasopharyngeal carcinoma(NPC)is endemic to southern China.Currently,its treatment and prognosis reply primarily on the TNM staging system and EBV-DNA testing;however,these parameters have limitations in fully capturing the tumor's biological heterogeneity and the host's immunonutritional status.In recent years,systemic inflammatory and nutritional indices,such as the neutrophil-to-lymphocyte ratio(NLR),systemic immune-inflammation index(SII),pan-immune-inflammation value(PIV),prognostic nutritional index(PNI),and skeletal muscle index(SMI),have proven effective for assessing systemic inflammation and nutritional status.Accumulating evidence has demonstrated that these indicators are closely associated with treatment response,progression-free survival(PFS),and overall survival(OS)in NPC patients,and also show promise in predicting the efficacy of immune checkpoint inhibitors.This review aims to systematically elaborate on the prognostic value of these inflammatory and nutritional indicators in the context of NPC immunotherapy,to inform the development of individualized precision treatment strategies.关键词
鼻咽癌/炎症营养指标/预后评估/免疫治疗Key words
Nasopharyngeal carcinoma/Inflammatory and nutritional indicators/Prognostic assessment/Immunotherapy分类
医药卫生引用本文复制引用
蔡明磊,鲁瑛,周亚娟..免疫治疗时代下炎症营养指标对鼻咽癌的预后预测价值研究进展[J].肿瘤防治研究,2026,53(3):226-232,7.基金项目
Hubei Provincial Natural Science Foundation(No.2025AFB849) （No.2025AFB849）
Scientific Research Project of Hubei Provincial Health Commission(No.WJ2025M110) （No.WJ2025M110）
Hubei Province's Young Top-notch Medical Talent Program(No.EWT2023-65) （No.EWT2023-65）
Wuhan City's Key Medical Talent Program(No.WWT2018-116) 湖北省自然科学基金(2025AFB849) （No.WWT2018-116）
湖北省卫生健康委科研项目(WJ2025M110) （WJ2025M110）
湖北省医学青年拔尖人才项目(EWT2023-65) （EWT2023-65）
武汉市医学骨干人才项目(WWT2018-116) （WWT2018-116）
