中医药临床杂志2026，Vol.38Issue(3)：449-455,7.DOI:10.16448/j.cjtcm.2026.0307
基于肾-髓-脑-骨轴探讨骨质疏松症的发病机制
Exploring the Pathogenesis of Osteoporosis based on the Kidney-marrow-brain-bone Axis
摘要
Abstract
Osteoporosis(OP)is a systemic bone metabolic disease characterized by decreased bone mass and de-struction of bone micro-structure.Its pathogenesis is complex and involves multi-system interactions.In recent years,increasing evidence suggests that a cross-organ regulatory network established between the central nervous system and the skeletal system through the"kidney-marrow-brain-bone"axis plays a crucial role in the pathogenesis of OP.This article aims to elucidate the regulatory mechanisms of the central nervous system on bone metabolism and the feed-back mechanisms of the skeletal system to the central nervous system from this emerging perspective of the"kidney-marrow-brain-bone"axis,comprehensively analyzing ancient Chinese medical texts,modern neuroscience research findings,and clinical data,and to explore new mechanisms of osteoporosis pathogenesis.关键词
骨质疏松症/脑骨轴/骨代谢/发病机制Key words
Osteoporosis/Brain-bone axis/Bone metabolism/Pathogenesis分类
医药卫生引用本文复制引用
陈莹莹,江雨,许淼淼,许晶晶,胡锦刚,陈朝晖..基于肾-髓-脑-骨轴探讨骨质疏松症的发病机制[J].中医药临床杂志,2026,38(3):449-455,7.基金项目
亳州职业技术学院第一批"医疗服务与保障能力提升补助"专项课题(亳职院科[2023]8号) （亳职院科[2023]8号）
