康复学报2026，Vol.36Issue(3)：145-152,8.DOI:10.3724/SP.J.1329.2026.03001
脑损伤精准康复新范式:多模态脑功能评估与个体化神经调控
New Paradigms for Precision Rehabilitation of Brain Injury:Multimodal Brain Function Detection and Individualized Neuromodulation
摘要
Abstract
In patients with brain injury,conventional clinical paradigm based on macro imaging and behavioral scales fails to achieve precise localization and dynamic assessment of neural functions and network connectivity.It is also difficult to effectively predict the recovery potential of neural plasticity,thereby limiting the improvement of rehabilitation outcomes.This article systemati-cally reviews recent advances in novel technologies for brain function detection and neuromodulation in brain injury,and explores their role in transitioning brain injury rehabilitation from a standardized model to an individualized and precise model.In the area of brain function detection,technologies have evolved from assessing static structures to evaluating dynamic networks.High-density electroencephalography significantly enhances spatial localization,which enables the precise identification of electroencephalograph-ic rhythm abnormalities in the prodromal stage of cognitive decline,assessment of post-stroke interhemispheric inhibition imbal-ance,and evaluation of level of consciousness.Functional near-infrared spectroscopy can reflect abnormal bilateral motor cortex ac-tivation patterns in stroke patients during motor tasks.Functional magnetic resonance imaging studies have revealed that alterations in functional connectivity within the default mode network were closely associated with the recovery of cognitive and motor func-tions after brain injury.Multimodal fusion technology enables simultaneous electroencephalogram and functional magnetic reso-nance imaging data acquisition.The combination of their respective advantages in temporal and spatial resolution significantly im-proves diagnostic efficacy in consciousness level assessment.Neuromodulation technologies are becoming increasingly precise and individualized.Navigated transcranial magnetic stimulation and deep transcranial magnetic stimulation enable precise intervention on specific cortical and deep brain areas.High definition transcranial direct current stimulation has been proven to be effective in en-hancing the consciousness level in patients with disorders of consciousness and promoting upper limb functional recovery in stroke patients.Deep brain stimulation can significantly improve the prognosis in some patients with disorders of consciousness.The tran-scranial magnetic stimulation-electroencephalogram paradigm allows direct quantification of cortical excitability and network con-nectivity.Based on a closed-loop paradigm,responsive neurostimulation achieves real-time monitoring and automatic intervention of abnormal epileptic electrical activity.However,the realization of precision rehabilitation for brain injury still faces many challeng-es,including the complexity of multimodal data fusion,the lack of individualized biomarkers,insufficient understanding of underly-ing mechanisms,and difficulties in clinical translation.Future research should focus on constructing a closed-loop neuromodulation system based on multimodal sensing,exploring novel paradigms for spatiotemporal precision and synergistic modulation,and estab-lishing a rehabilitation assessment-intervention framework integrating standardization and individualization.These efforts will drive the refinement and development of a precision rehabilitation system for brain injury.关键词
脑损伤/脑功能评估/神经调控/多模态融合/精准定位/精准康复Key words
brain injury/brain function assessment/neuromodulation/multimodal fusion/precise localization/precise rehabili-tation引用本文复制引用
吴毅..脑损伤精准康复新范式:多模态脑功能评估与个体化神经调控[J].康复学报,2026,36(3):145-152,8.基金项目
上海市科学技术委员会项目(22Y31900202,23Y11906300) （22Y31900202,23Y11906300）
