国际生殖健康/计划生育杂志2026，Vol.45Issue(2)：154-159,6.DOI:10.12280/gjszjk.20250274
维生素D在多囊卵巢综合征患者辅助生殖中的应用进展
The Impact of Vitamin D on Assisted Reproductive Technology Outcomes in Women with Polycystic Ovary Syndrome
摘要
Abstract
Polycystic ovary syndrome(PCOS),a prevalent endocrine and metabolic disorder among women of reproductive age,is one of the primary causes of female infertility.Recent studies have demonstrated that the level of vitamin D(VD)was correlated with the clinical characteristics and pathogenesis of PCOS,influencing reproductive function and outcomes of assisted reproductive technology(ART).VD may improve ART outcomes through multiple mechanisms:by regulating the hypothalamic-pituitary-ovarian axis to improve insulin resistance and hyperandrogenemia,thereby optimizing follicular development and ovulation;and by modulating the endometrial microenvironment via key receptivity genes and uterine adipokines to support embryo implantation.However,its impact on ART outcomes of PCOS women remains controversial,with the indeterminacy in optimal dosage,route and safety.Future large-scale,high-quality randomized controlled trials are needed to clarify its effects on pregnancy outcomes and establish standardized supplementation strategies.关键词
多囊卵巢综合征/不育,女性/维生素D/生殖技术,辅助/妊娠结局Key words
Polycystic ovary syndrome/Infertility,female/Vitamin D/Reproductive techniques,assisted/Pregnancy outcome引用本文复制引用
孔璟,于岚,张翠莲..维生素D在多囊卵巢综合征患者辅助生殖中的应用进展[J].国际生殖健康/计划生育杂志,2026,45(2):154-159,6.基金项目
河南省重点研发专项项目(251111312200) （251111312200）
