国际生殖健康/计划生育杂志2026，Vol.45Issue(2)：160-166,7.DOI:10.12280/gjszjk.20260004
氨基酸代谢与多囊卵巢综合征的研究进展
Research Progress on Amino Acid Metabolism and Polycystic Ovary Syndrome
摘要
Abstract
Polycystic ovary syndrome(PCOS)is a common gynecological endocrine disorder characterized by hyperandrogenism,ovulatory dysfunction and polycystic ovarian morphology as its core features.It is often accompanied by insulin resistance(IR),metabolic syndrome and an increased risk of type 2 diabetes,impairing the reproductive health and metabolic functions of women of childbearing age.In recent years,metabolomic studies have revealed that amino acid metabolic disorders are closely associated with the occurrence and progression of PCOS.Branched-chain amino acid(BCAA)interfere with insulin signaling by activating the mammalian target of rapamycin(mTOR)pathway;abnormal metabolism of aromatic amino acid(AAA)impairs oocyte development and exacerbates inflammation;an imbalance in glutamine/glutamic acid(Gln/Glu)aggravates IR and hyperandrogenism;and homocysteine(Hcy)exacerbates IR through endoplasmic reticulum stress and inflammation.Targeting these metabolic abnormalities,intervention strategies include lifestyle modifications and nutritional supplements such as insulin sensitizers(e.g.,metformin),inositol and N-acetylcysteine,which can improve IR,optimize follicular development and pregnancy outcomes.This paper reviews the mechanisms underlying the role of key amino acid metabolic disorders in PCOS and the corresponding intervention strategies,aiming to provide a new perspective for the precise diagnosis and treatment of PCOS.关键词
多囊卵巢综合征/氨基酸类/代谢/胰岛素抵抗/代谢综合征Key words
Polycystic ovary syndrome/Amino acids/Metabolism/Insulin resistance/Metabolic syndrome引用本文复制引用
王海韵,魏嘉豫,兰甜宁,张柯欣,张慧英,田文艳..氨基酸代谢与多囊卵巢综合征的研究进展[J].国际生殖健康/计划生育杂志,2026,45(2):160-166,7.基金项目
天津市卫生健康科技项目(TJWJ2025RC001) （TJWJ2025RC001）
