中国实用神经疾病杂志2026，Vol.29Issue(2)：177-182,6.DOI:10.12083/SYSJ.251771
伴意识障碍颞叶癫痫的PET代谢脑网络及枢纽重构
PET metabolic brain network and Hub reorganization in temporal lobe epilepsy with impaired awareness seizures
摘要
Abstract
Objective To investigate the alterations in graph-theoretical properties and Hub nodes of metabolic brain networks in patients with temporal lobe epilepsy with impaired awareness seizures(TLE-IAS),and explore the mechanisms of its characteristic metabolic network reorganization.Methods A total of 193 patients(TLE-IAS group)with TLE-IAS who underwent 18F-FDG PET/CT at the Department of Nuclear Medicine,the Second Hospital of Lanzhou University between January 2018 and January 2025 were retrospectively included,along with 193 controls(control group)without central nervous system disorders.At the group level,Pearson correlation coefficients between each brain region pair were calculated for both groups to construct PET metabolic brain networks for the TLE-IAS group and the control group.Non-parametric permutation testing with 1 000 iterations was then applied to compare group differences in graph-theoretical metrics and Hub node distribution.Results Compared with the control group,globally weakened metabolic connectivity was exhibited in the TLE-IAS patient group.Graph-theoretical analysis revealed a significantly increased Lp and significantly decreased Cp and mean degree(P<0.05).However,Eg and Eloc showed no significant group differences after FDR correction.Thirteen Hub nodes were identified in the control group,compared to eight in the TLE-IAS group.Furthermore,a spatial reorganization of hubs was demonstrated in patients,characterized by a shift from the default mode network toward the limbic system and primary sensory cortices.Conclusion TLE-IAS patients exhibit widespread weakened metabolic connectivity,impaired network transmission efficiency and information processing capacity,alongside a reduced number of Hub nodes and their spatial reorganization.关键词
颞叶癫痫/正电子发射断层/标准化摄取比率值/意识/代谢脑网络/图论属性/Hub节点Key words
Temporal lobe epilepsy/Positron emission tomography/Standardized uptake value ratio/Awareness/Metabolic brain network/Graph-theoretical properties/Hub node分类
医药卫生引用本文复制引用
肖静可,杨帆,张瀚林,柳江燕..伴意识障碍颞叶癫痫的PET代谢脑网络及枢纽重构[J].中国实用神经疾病杂志,2026,29(2):177-182,6.基金项目
甘肃省科技厅联合基金项目(编号:24JRRA922) （编号:24JRRA922）
