黑龙江畜牧兽医Issue(4)：42-48,7.DOI:10.13881/j.cnki.hljxmsy.2025.09.0115
纳米抗体在猪病诊断、治疗及疫苗研发中的应用研究进展
Research progress on the application of nanobodies in the diagnosis,treatment and vaccine development of swine diseases
摘要
Abstract
Porcine diseases severely restrict the development of the global swine industry and pose multiple threats to economic development,food safety,and public health.However,current traditional prevention and control technologies,including diagnostic techniques,therapeutic approaches,and vaccine prevention,still have significant limitations in terms of sensitivity,cost,broad-spectrum capability,tissue penetration,and the response to highly variable pathogens,which could not meet the demands of prevention and control.Nanobodies(Nbs),a novel class of genetically engineered antibodies derived from heavy-chain antibodies of camelids,present a promising solution for porcine disease control due to their unique advantages,including small molecular size,high stability,strong binding affinity,ease of large-scale production,and engineering modification.This review systematically discussed the structure and characteristics of nanobodies and comprehensively reviewed their application progress in diagnostic technologies,therapeutic strategies,and vaccine development for major porcine diseases,such as porcine reproductive and respiratory syndrome(PRRS),African swine fever(ASF),porcine epidemic diarrhea(PED),classical swine fever(CSF),and porcine circovirus disease(PCVD),aiming to provide new insights and theoretical foundations for the efficient prevention and control of porcine diseases.关键词
纳米抗体/猪病/诊断技术/治疗/疫苗研发Key words
nanobodies/swine diseases/diagnostic technologies/treatment/vaccine development分类
农业科技引用本文复制引用
胡湘云,曹艳红,陈少梅,宣泽义,黄光云,潘锐,罗蒙和,潘婕,黄亭菊,孙如玉,陆世财,陈宝剑..纳米抗体在猪病诊断、治疗及疫苗研发中的应用研究进展[J].黑龙江畜牧兽医,2026,(4):42-48,7.基金项目
广西自然科学基金资助项目(2023GXNSFBA026204) （2023GXNSFBA026204）
"十四五"国家重点研发计划项目(2024YFD1800505) （2024YFD1800505）
